Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.
Anemia
/ therapy
Blood Component Transfusion
Cardiac Surgical Procedures
/ adverse effects
Cardiopulmonary Bypass
/ adverse effects
Child
Critical Care
Critical Illness
/ therapy
Erythrocyte Transfusion
Evidence-Based Medicine
/ methods
Extracorporeal Membrane Oxygenation
Hemorrhage
/ etiology
Humans
Infant, Newborn
Plasma
Platelet Transfusion
Journal
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
ISSN: 1529-7535
Titre abrégé: Pediatr Crit Care Med
Pays: United States
ID NLM: 100954653
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
entrez:
6
1
2022
pubmed:
7
1
2022
medline:
6
5
2022
Statut:
ppublish
Résumé
To present the recommendations and consensus statements with supporting literature for plasma and platelet transfusions in critically ill neonates and children undergoing cardiac surgery with cardiopulmonary bypass or supported by extracorporeal membrane oxygenation from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. Not applicable. Critically ill neonates and children following cardiopulmonary bypass or supported by extracorporeal membrane oxygenation. None. A panel of nine experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill neonates and children following cardiopulmonary bypass or supported by extracorporeal membrane oxygenation. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed one good practice statement, two recommendations, and three expert consensus statements. Whereas viscoelastic testing and transfusion algorithms may be considered, in general, evidence informing indications for plasma and platelet transfusions in neonatal and pediatric patients undergoing cardiac surgery with cardiopulmonary bypass or those requiring extracorporeal membrane oxygenation support is lacking.
Identifiants
pubmed: 34989703
doi: 10.1097/PCC.0000000000002856
pii: 00130478-202201001-00003
pmc: PMC8769357
mid: NIHMS1746605
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25-e36Subventions
Organisme : NINDS NIH HHS
ID : R01 NS106292
Pays : United States
Organisme : NHLBI NIH HHS
ID : R13 HL154544
Pays : United States
Informations de copyright
Copyright © 2022 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
Déclaration de conflit d'intérêts
Dr. Emani disclosed that he is a consultant for Chiesi Pharmaceuticals. Dr. Steiner received funding from Pumps for Kids, Infants, and Neonates (PumpKIN) Data Safety Monitoring Board and HealthCore. Drs. Nellis and Bembea received support for article research from the National Institutes of Health. Dr. Bembea’s institution received funding from the National Institute of Neurological Disorders and Stroke (R01NS106292), the National Institute of Child Health and Human Development, and Grifols Investigator Sponsored Research Grant. The remaining authors have disclosed that they do not have any potential conflicts of interest.
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