Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders.
Antibody
CSF
Direct ELISA
IgG1
IgG3
Immunoglobulin
Multiple Sclerosis
Serum
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
11
10
2021
accepted:
23
12
2021
pubmed:
7
1
2022
medline:
6
1
2023
entrez:
6
1
2022
Statut:
ppublish
Résumé
Increased intrathecal IgG and oligoclonal bands (OCB) are seminal features of multiple sclerosis (MS). Although no such differences in MS blood total IgG antibodies have been reported, serum OCB are a common and persistent finding in MS and have a systemic source. Recent studies showed that IgG3
Identifiants
pubmed: 34989971
doi: 10.1007/s11481-021-10048-x
pii: 10.1007/s11481-021-10048-x
doi:
Substances chimiques
Oligoclonal Bands
0
Biomarkers
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
526-537Subventions
Organisme : NIMH NIH HHS
ID : R21 MH118174
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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