Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice.

Adenovirus Colon cancer PD-L1 blockade therapy PD-L1 inhibitory peptide PD-L1 inhibitory peptide secretory gene

Journal

Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 24 11 2021
revised: 18 12 2021
accepted: 21 12 2021
pubmed: 7 1 2022
medline: 7 1 2022
entrez: 6 1 2022
Statut: ppublish

Résumé

A novel peptide that interferes with the PD-1/PD-L1 immune checkpoint pathway, termed PD-L1 inhibitory peptide 3 (PD-L1ip3), was computationally designed, experimentally validated for its specific binding to PD-L1, and evaluated for its antitumor effects in cell culture and in a mouse colon carcinoma syngeneic murine model. In several cell culture studies, direct treatment with PD-L1ip3, but not a similar peptide with a scrambled sequence, substantially increased death of CT26 colon carcinoma cells when co-cultured with murine CD8

Identifiants

DOI: 10.1016/j.tranon.2021.101337 PMID: 34990908 PMC: PMC8741604
pubmed: 34990908
pii: S1936-5233(21)00328-4
doi: 10.1016/j.tranon.2021.101337
pmc: PMC8741604
pii:
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101337

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103418
Pays : United States
Organisme : NCI NIH HHS
ID : R15 CA219919
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

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Auteurs

Susumu Ishiguro (S)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: isusumu@vet.ksu.edu.

Deepa Upreti (D)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: deepa07@vet.ksu.edu.

Molly Bassette (M)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA; Department of Pathology, University of California, San Francisco, CA 94143, USA. Electronic address: Molly.Bassette@ucsf.edu.

E R Azhagiya Singam (ERA)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA; Molecular Graphics and Computation Facility, College of Chemistry, University of California, Berkeley, CA 94720, USA. Electronic address: eazhagiy@berkeley.edu.

Ravindra Thakkar (R)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: ravithakkar@vet.ksu.edu.

Mayme Loyd (M)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: mkloyd@ksu.edu.

Makoto Inui (M)

Departments of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan. Electronic address: minui@yamaguchi-u.ac.jp.

Jeffrey Comer (J)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: jeffcomer@ksu.edu.

Masaaki Tamura (M)

Departments of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA. Electronic address: mtamura@vet.ksu.edu.

Classifications MeSH