Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration.
CNS
axonal regeneration
axons
extracellular histones
inhibitory molecules
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
06
2021
revised:
05
08
2021
accepted:
30
08
2021
entrez:
7
1
2022
pubmed:
8
1
2022
medline:
8
1
2022
Statut:
epublish
Résumé
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Triple knockout mice lacking the major myelin-associated inhibitors do not display spontaneous regeneration after injury, indicating the presence of other inhibitors. Searching for such inhibitors, we have detected elevated levels of histone H3 in human CSF 24 h after spinal cord injury. Following dorsal column lesions in mice and optic nerve crushes in rats, elevated levels of extracellular histone H3 were detected at the injury site. Similar to myelin-associated inhibitors, these extracellular histones induced growth cone collapse and inhibited neurite outgrowth. Histones mediate inhibition through the transcription factor Y-box-binding protein 1 and Toll-like receptor 2, and these effects are independent of the Nogo receptor. Histone-mediated inhibition can be reversed by the addition of activated protein C
Identifiants
pubmed: 34993473
doi: 10.1093/braincomms/fcab271
pii: fcab271
pmc: PMC8728726
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab271Informations de copyright
© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Nat Med. 2011 Dec 25;18(1):166-71
pubmed: 22198277
Neuropathol Appl Neurobiol. 1999 Oct;25(5):425-32
pubmed: 10564533
J Neurosci. 2016 Mar 9;36(10):3079-91
pubmed: 26961960
Methods. 2014 Mar 15;66(2):246-55
pubmed: 23962836
Science. 2008 May 16;320(5878):903-9
pubmed: 18487186
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1884-91
pubmed: 22628431
Neuron. 1994 Sep;13(3):757-67
pubmed: 7522484
Brain Res Rev. 2007 Apr;54(1):1-18
pubmed: 17222456
Science. 2002 Aug 16;297(5584):1190-3
pubmed: 12089450
Ann Med. 2005;37(8):556-67
pubmed: 16338758
Cell Death Dis. 2016 Dec 8;7(12):e2518
pubmed: 27929534
BMC Biochem. 2008 Sep 15;9:23
pubmed: 18793384
Stem Cells Transl Med. 2014 Jan;3(1):18-31
pubmed: 24324277
Nat Biotechnol. 2010 May;28(5):511-5
pubmed: 20436464
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Biophys J. 1986 Oct;50(4):693-712
pubmed: 3779007
Neuron. 2002 Jul 18;35(2):283-90
pubmed: 12160746
J Neurosci. 1999 Sep 1;19(17):7537-47
pubmed: 10460260
J Neurosci. 2010 May 19;30(20):6825-37
pubmed: 20484625
J Neurosci. 2004 Jul 14;24(28):6402-9
pubmed: 15254096
J Biol Chem. 2015 Jun 26;290(26):16343-56
pubmed: 25947372
Nat Rev Neurosci. 2003 Sep;4(9):703-13
pubmed: 12951563
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13798-803
pubmed: 17693552
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Commun. 2019 Aug 21;10(1):3756
pubmed: 31434897
Neuron. 1999 Jan;22(1):89-101
pubmed: 10027292
Nature. 2001 Jan 18;409(6818):341-6
pubmed: 11201742
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
F1000Res. 2013 Jul 08;2:148
pubmed: 24358859
Elife. 2017 Jan 30;6:
pubmed: 28134617
Neuron. 2016 May 4;90(3):437-51
pubmed: 27151637
J Neurosci. 2003 Jul 2;23(13):5393-406
pubmed: 12843238
Nat Med. 2009 Nov;15(11):1318-21
pubmed: 19855397
Science. 2009 Oct 23;326(5952):592-6
pubmed: 19833921
Thromb Res. 2016 May;141 Suppl 2:S62-4
pubmed: 27207428
Nature. 2002 Apr 11;416(6881):636-40
pubmed: 11948352