100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention.
Autoimmunity
Automated Insulin Delivery
Insulin
Insulin Autoantibody
Insulin Immunotherapy
Insulin device
Insulin pump
Tolerance
Treg
Type 1 Diabetes
Journal
Med (New York, N.Y.)
ISSN: 2666-6340
Titre abrégé: Med
Pays: United States
ID NLM: 101769215
Informations de publication
Date de publication:
08 10 2021
08 10 2021
Historique:
entrez:
7
1
2022
pubmed:
8
1
2022
medline:
8
1
2022
Statut:
ppublish
Résumé
In this review, we bring our personal experiences to showcase insulin from its breakthrough discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and potential cause of type 1 diabetes and eventually as an opportunity to prevent autoimmune diabetes. The work covers the birth of insulin to treat patients, which is now 100 years ago, the development of human insulin, insulin analogues, devices, and the way into automated insulin delivery, the realization that insulin is the primary autoimmune target of type 1 diabetes in children, novel approaches of immunotherapy using insulin for immune tolerance induction, the possible limitations of insulin immunotherapy, and an outlook how modern vaccines could remove the need for another 100 years of insulin therapy.
Identifiants
pubmed: 34993499
doi: 10.1016/j.medj.2021.08.003
pmc: PMC8730368
mid: NIHMS1759573
doi:
Substances chimiques
Autoantigens
0
Insulin
0
Insulin, Regular, Human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
1120-1137Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK063836
Pays : United States
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