An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration.
Animals
Bronchoalveolar Lavage Fluid
/ chemistry
COVID-19
/ complications
Gonadotropin-Releasing Hormone
/ antagonists & inhibitors
Growth Hormone-Releasing Hormone
Inflammation
/ etiology
Lipopolysaccharides
Male
Mice
Mice, Inbred C57BL
Proteins
/ chemistry
Pulmonary Edema
/ etiology
Reactive Oxygen Species
Respiratory Distress Syndrome
/ drug therapy
SARS-CoV-2
Inflammation
Lung
Permeability
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
08
11
2021
accepted:
30
11
2021
revised:
28
11
2021
pubmed:
8
1
2022
medline:
4
2
2022
entrez:
7
1
2022
Statut:
ppublish
Résumé
Growth Hormone-Releasing Hormone (GHRH) is a neuropeptide regulating the release of Growth Hormone (GH) from the anterior pituitary gland, and acts as a growth factor in a diverse variety of tissues. GHRH antagonists (GHRHAnt) have been developed to counteract those events, and the beneficial effects of those peptides toward homeostasis have been associated with anti-inflammatory activities. Our lab is interested in delineating the mechanisms governing endothelial barrier function. Our goal is to establish new grounds on the development of efficient countermeasures against Acute Respiratory Distress Syndrome (ARDS), which has been associated with thousands of deaths worldwide due to COVID-19. Herein we demonstrate in vivo that GHRHAnt suppresses LPS-induced increase in bronchoalveolar lavage fluid (BALF) protein concentration, thus protecting the lungs against edema and inflammation.
Identifiants
pubmed: 34993559
doi: 10.1007/s00011-021-01531-5
pii: 10.1007/s00011-021-01531-5
pmc: PMC8736306
doi:
Substances chimiques
Lipopolysaccharides
0
Proteins
0
Reactive Oxygen Species
0
Gonadotropin-Releasing Hormone
33515-09-2
Growth Hormone-Releasing Hormone
9034-39-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-185Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103424
Pays : United States
Organisme : Louisiana Board of Regents
ID : LEQSF(2019-22)-RD-A-26
Organisme : NIGMS NIH HHS
ID : 5P20 GM103424-20
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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