Genomic Alterations in Head and Neck Squamous Cell Carcinoma: Level of Evidence According to ESMO Scale for Clinical Actionability of Molecular Targets (ESCAT).

Cell Cycle / genetics DNA Repair / genetics Head and Neck Neoplasms / genetics Humans MAP Kinase Signaling System / genetics Receptor Protein-Tyrosine Kinases / metabolism Squamous Cell Carcinoma of Head and Neck / genetics

Journal

JCO precision oncology
ISSN: 2473-4284
Titre abrégé: JCO Precis Oncol
Pays: United States
ID NLM: 101705370

Informations de publication

Date de publication:
11 2021
Historique:
entrez: 7 1 2022
pubmed: 8 1 2022
medline: 29 3 2022
Statut: ppublish

Résumé

Development of high-throughput technologies helped to decipher tumor genomic landscapes revealing actionable molecular alterations. We aimed to rank the level of evidence of recurrent actionable molecular alterations in head and neck squamous cell carcinoma (HNSCC) on the basis of the European Society for Medical Oncology (ESMO) Scale for Clinical Actionability of Molecular Targets (ESCAT) to help the clinicians prioritize treatment. We identified actionable alterations in 33 genes.

Identifiants

DOI: 10.1200/PO.20.00280 PMID: 34994597
pubmed: 34994597
doi: 10.1200/PO.20.00280
doi:

Substances chimiques

Receptor Protein-Tyrosine Kinases EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Pagination

215-226

Auteurs

Grégoire Marret (G)

Hôpital Européen Georges Pompidou, Paris, France.

Ivan Bièche (I)

Department of Genetics, Institut Curie, Paris Descartes University, Paris, France.
INSERM U1016 Research Unit, Cochin Institute, Paris, France.

Célia Dupain (C)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Edith Borcoman (E)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Pauline du Rusquec (P)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Francesco Ricci (F)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Ségolène Hescot (S)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Marie-Paule Sablin (MP)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Patricia Tresca (P)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Diana Bello (D)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Coraline Dubot (C)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Delphine Loirat (D)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Maxime Frelaut (M)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Charlotte Lecerf (C)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

Christophe Le Tourneau (C)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
INSERM U900, Institut Curie, Mines Paris Tech, Saint-Cloud, France.
Paris-Saclay University, Paris, France.

Maud Kamal (M)

Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Genomic Alterations in Head and Neck Squamous...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Genomic Alterations in Head and Neck Squamous...