The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease.
Biomarker
Fibrosis
Natural History
Stratified Medicine
Systems Biology
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
25
07
2021
revised:
20
09
2021
accepted:
23
09
2021
pubmed:
8
1
2022
medline:
6
4
2022
entrez:
7
1
2022
Statut:
ppublish
Résumé
Inflammatory bowel disease is characterized by significant interindividual heterogeneity. With a wider selection of pharmacologic and nonpharmacologic interventions available and in advanced developmental stages, a priority for the coming decade is to determine accurate methods of predicting treatment response and disease course. Precision medicine strategies will allow tailoring of preventative and therapeutic decisions to individual patient needs. In this review, we consider the future of precision medicine in inflammatory bowel disease. We discuss the critical need to extend from research focused on short-term symptomatic response to integrative multi-omic systems biology strategies to identify and validate biomarkers that underpin precision approaches. Crucially, the international community has collective responsibility to provide well-phenotyped and -curated longitudinal datasets for scientific discovery and validation. Research must also study broader aspects of the immune response, including components of the extracellular matrix, to better understand biological pathways initiating and perpetuating tissue fibrosis and longer-term disease complications.
Identifiants
pubmed: 34995532
pii: S0016-5085(21)04069-5
doi: 10.1053/j.gastro.2021.09.077
pmc: PMC8983496
mid: NIHMS1764262
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1525-1542Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK110415
Pays : United States
Organisme : Medical Research Council
ID : MR/T032162/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK123233
Pays : United States
Informations de copyright
Copyright © 2022 AGA Institute. Published by Elsevier Inc. All rights reserved.
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