The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community.

BACKGROUND

Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear.

METHODS

We examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of forced expiratory volume in 1 s (FEV

RESULTS

We found lower FEV

CONCLUSIONS

In a large, community-based cohort of adults, we found lower FEV

Informations de copyright

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Déclaration de conflit d'intérêts

Conflict of interest: J. McNeill has nothing to disclose. Conflict of interest: A. Chernofsky has nothing to disclose. Conflict of interest: M. Nayor reports grants from the NIH, during the conduct of the study. Conflict of interest: F.N. Rahaghi has nothing to disclose. Conflict of interest: R. San Jose Estepar has contracts with Lung Biotechnology, Insmed and Boehringer Ingelheim, receives consulting fees from Leuko Labs, and has stock options in Quantitative Imaging Solutions. Conflict of interest: G. Washko reports grants from the NIH, DoD, Boehringer Ingelheim, Janssen Pharmaceuticals, BTG Therapeutics, Pulmonx, Lung Biotechnology and Insmed; participation in advisory boards and consultancies for Boehringer Ingelheim, CSL Behring, Novartis, Phillips and Vertex Pharmaceuticals; is a co-founder and equity shareholder in Quantitative Imaging Solutions, a company that provides consulting services for image and data analytics; finally, the author's spouse works for Biogen. Conflict of interest: A. Synn reports grants from the American Lung Association and NHLBI, outside the submitted work. Conflict of interest: R.S. Vasan has nothing to disclose. Conflict of interest: G. O'Connor has nothing to disclose. Conflict of interest: M.G. Larson has nothing to disclose. Conflict of interest: J.E. Ho reports grants from the NIH/NHLBI, during the conduct of the study; research support from Gilead Sciences and Bayer AG, and research supplies from EcoNugenics, outside the submitted work. Conflict of interest: G.D. Lewis reports grants from Amgen, Cytokinetics, AstraZeneca, Applied Therapeutics and Sonivie, personal fees and other for advisory board work from American Regent, outside the submitted work.