FASN-dependent de novo lipogenesis is required for brain development.
lipogenesis
neural stem cell
neurogenesis
polarity
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
accepted:
23
11
2021
entrez:
8
1
2022
pubmed:
9
1
2022
medline:
22
2
2022
Statut:
ppublish
Résumé
Fate and behavior of neural progenitor cells are tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells govern progenitor function. However, the role of de novo lipogenesis, which is the conversion of glucose into fatty acids through the multienzyme protein fatty acid synthase (FASN), for brain development remains unknown. Using Emx1Cre-mediated, tissue-specific deletion of
Identifiants
pubmed: 34996870
pii: 2112040119
doi: 10.1073/pnas.2112040119
pmc: PMC8764667
pii:
doi:
Substances chimiques
FASN protein, human
EC 2.3.1.85
Fasn protein, mouse
EC 2.3.1.85
Fatty Acid Synthase, Type I
EC 2.3.1.85
Fatty Acid Synthases
EC 2.3.1.85
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Informations de copyright
Copyright © 2022 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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