Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement.
Adult
Bone Marrow
/ diagnostic imaging
Chronic Pain
/ diagnostic imaging
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Low Back Pain
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Predictive Value of Tests
Randomized Controlled Trials as Topic
Spine
/ diagnostic imaging
Transcriptome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
received:
20
06
2021
accepted:
16
12
2021
entrez:
8
1
2022
pubmed:
9
1
2022
medline:
24
2
2022
Statut:
epublish
Résumé
Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored the pathobiology of these lesions using profiling of gene expression in blood, coupled with an edema-sensitive MRI technique known as short tau inversion recovery (STIR) imaging. STIR images and total RNA from blood were collected from 96 patients with chronic LBP and MC type I, the most inflammatory MC state. We found the expression of 37 genes significantly associated with STIR signal volume, ten genes with edema abundancy (a constructed combination of STIR signal volume, height, and intensity), and one gene with expression levels significantly associated with maximum STIR signal intensity. Gene sets related to interferon signaling, mitochondrial metabolism and defense response to virus were identified as significantly enriched among the upregulated genes in all three analyses. Our results point to inflammation and immunological defense as important players in MC biology in patients with chronic LBP.
Identifiants
pubmed: 34997115
doi: 10.1038/s41598-021-04189-5
pii: 10.1038/s41598-021-04189-5
pmc: PMC8741947
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
215Subventions
Organisme : Helse Sør-Øst RHF
ID : 2015090
Organisme : Helse Vest
ID : HV 911938
Investigateurs
Audny Anke
(A)
Bendik Slagsvold Winsvold
(BS)
Britt Elin Lurud
(BE)
Christian Hellum
(C)
Erling Andersen
(E)
Fredrik Granvigen
(F)
Gunn Hege Marchand
(GH)
Guro Kjos
(G)
Hege Andersen
(H)
Hilde Presberg
(H)
Ida Beate Østhus
(IB)
Jens Ivar Brox
(JI)
Jörg Aßmus
(J)
Karianne Wiger Gammelsrud
(KW)
Knut Morten Huneide
(KM)
Lars Grøvle
(L)
Mads Peder Rolfsen
(MP)
Maja Wilhelmsen
(M)
Margreth Grotle
(M)
Marianne Thorsø
(M)
Olav Lutro
(O)
Øystein Petter Nygaard
(ØP)
Sigrun Randen
(S)
Siv Krüger Claussen
(SK)
Terese Fors
(T)
Thomas Istvan Kadar
(TI)
Thor Einar Holmgard
(TE)
Veronica Sørensen
(V)
Vidar Rao
(V)
Informations de copyright
© 2022. The Author(s).
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