BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment.
Adult
Brain Mapping
Brain Waves
Brain-Derived Neurotrophic Factor
/ genetics
Cognition
France
Frontal Lobe
/ physiopathology
Genetic Predisposition to Disease
Humans
Magnetic Resonance Imaging
Male
Memory
Memory Disorders
/ diagnosis
Neuronal Plasticity
Phenotype
Polymorphism, Genetic
Risk Factors
Spain
Transcranial Direct Current Stimulation
/ adverse effects
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
received:
23
09
2021
accepted:
16
12
2021
entrez:
8
1
2022
pubmed:
9
1
2022
medline:
24
2
2022
Statut:
epublish
Résumé
The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual differences to TMS, and may inform future, more individually-tailored rTMS interventions.
Identifiants
pubmed: 34997117
doi: 10.1038/s41598-021-04175-x
pii: 10.1038/s41598-021-04175-x
pmc: PMC8741781
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
176Subventions
Organisme : NIH HHS
ID : NIH R01 MH100186
Pays : United States
Organisme : NIH HHS
ID : R21 HD07616
Pays : United States
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : MICIU/FEDER
Organisme : Generalitat de Catalunya
ID : 2017SGR748
Organisme : the H2020 Marie S. Curie ITN-ETN
ID : BBDiag
Organisme : Harvard Catalyst
ID : NCRR and the NCATS NIH, UL1 RR025758
Organisme : NIH HHS
ID : R01 NS073601
Pays : United States
Organisme : Spanish Ministry of Economy and Competitiveness
ID : BES-2016-077620
Organisme : NIH HHS
ID : R21 MH099196
Pays : United States
Organisme : NIH HHS
ID : R01 HD069776
Pays : United States
Organisme : Seventh Framework Programme
ID : FP7/2007-2013
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : RTI2018-095181-B-C21
Organisme : DARPA
ID : HR001117S0030
Organisme : NIH HHS
ID : R21 NS085491
Pays : United States
Organisme : NIH HHS
ID : R21 NS082870
Pays : United States
Organisme : Spanish Ministry of Education, Culture and Sport
ID : 12135072325-79
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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