Annual change in the extracellular fluid/intracellular fluid ratio and mortality in patients undergoing maintenance hemodialysis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
received:
20
07
2021
accepted:
20
12
2021
entrez:
8
1
2022
pubmed:
9
1
2022
medline:
1
3
2022
Statut:
epublish
Résumé
We aimed to investigate whether annual change in the extracellular fluid to intracellular fluid (ΔECF/ICF) ratio can accurately predict mortality in hemodialysis patients. Totally, 247 hemodialysis patients were divided into two groups according to the median baseline ECF/ICF ratio of 0.563 and ΔECF/ICF ≥ 0% or < 0% during the first year, respectively. Thereafter, they were divided into four groups according to each cutoff point and were followed up for mortality assessment. The ECF/ICF ratio increased from 0.566 ± 0.177 to 0.595 ± 0.202 in the first year (P = 0.0016). During the 3.4-year median follow-up, 93 patients died (42 cardiovascular-specific causes). The baseline ECF/ICF ≥ 0.563 and ΔECF/ICF ≥ 0% were independently associated with all-cause mortality (adjusted hazard ratio [aHR] 4.55, 95% confidence interval [CI] 2.60-7.98 and aHR 8.11, 95% CI 3.47-18.96, respectively). The aHR for ECF/ICF ≥ 0.563 and ΔECF/ICF ≥ 0% vs. ECF/ICF < 0.563 and ΔECF/ICF < 0% was 73.49 (95% CI 9.45-571.69). For model discrimination, adding the ΔECF/ICF (0.859) alone and both the baseline ECF/ICF and ΔECF/ICF (0.903) to the established risk model (0.746) significantly improved the C-index. Similar results were obtained for cardiovascular mortality. In conclusion, the ΔECF/ICF ratio could not only predict all-cause and cardiovascular mortality but also improve predictability of mortality in hemodialysis patients.
Identifiants
pubmed: 34997150
doi: 10.1038/s41598-021-04366-6
pii: 10.1038/s41598-021-04366-6
pmc: PMC8741928
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
242Informations de copyright
© 2022. The Author(s).
Références
J Am Soc Nephrol. 2014 Feb;25(2):381-9
pubmed: 24158987
Kidney Int. 2014 Sep;86(3):489-96
pubmed: 24918155
J Am Soc Nephrol. 2017 Aug;28(8):2491-2497
pubmed: 28473637
Am J Kidney Dis. 2001 Dec;38(6):1251-63
pubmed: 11728958
ASAIO J. 2018 Mar/Apr;64(2):245-252
pubmed: 28665828
Nutrients. 2020 Oct 29;12(11):
pubmed: 33138201
Nephrol Dial Transplant. 2009 May;24(5):1574-9
pubmed: 19131355
Kidney Int. 2008 Feb;73(4):391-8
pubmed: 18094682
J Am Soc Nephrol. 2002 Jan;13(1):177-183
pubmed: 11752035
Nephrol Dial Transplant. 2000 Jul;15(7):953-60
pubmed: 10862630
Lancet. 1999 May 29;353(9167):1838-42
pubmed: 10359409
PLoS One. 2017 Jan 18;12(1):e0170272
pubmed: 28099511
PLoS One. 2019 Feb 13;14(2):e0211988
pubmed: 30759133
Int J Artif Organs. 2002 Aug;25(8):762-9
pubmed: 12296460
Nephrol Dial Transplant. 2002;17 Suppl 11:28-31
pubmed: 12386254
Nutrients. 2018 Apr 12;10(4):
pubmed: 29649164
Stat Med. 2008 Jan 30;27(2):157-72; discussion 207-12
pubmed: 17569110
Nutrients. 2019 Nov 04;11(11):
pubmed: 31690024
Ther Apher Dial. 2015 Mar;19 Suppl 1:67-92
pubmed: 25817933
Nephron Clin Pract. 2012;122(1-2):44-52
pubmed: 23548410
Ren Fail. 2021 Dec;43(1):821-829
pubmed: 33966595
Kidney Int. 2004 Nov;66(5):2054-60
pubmed: 15496179
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
Nutr Clin Pract. 2007 Aug;22(4):389-405
pubmed: 17644693