The beginnings of biometrical psychiatric genetics: Studies of the insane diathesis 1905-1909.
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
17
12
2021
received:
04
07
2021
accepted:
22
12
2021
pubmed:
9
1
2022
medline:
3
5
2022
entrez:
8
1
2022
Statut:
ppublish
Résumé
The year 1900 saw not only the rediscovery of Mendel's hybridization studies but also the publication by Karl Pearson of his newly developed tetrachoric correlation which he used to study the parent-offspring resemblance for the "insane diathesis" in 1905. This was followed by more detailed reports by two of his students/associates: Heron in 1907 and Goring in 1909. Both calculated the tetrachoric correlation for insanity in parent-offspring and Heron for sib-sib pairs. Estimates ranged from approximately +0.30 to +0.60. These papers were statistically sophisticated but demonstrated minimal interest in the phenotype being studied. They are of historical interest because they laid the groundwork for biometrical psychiatric genetics which emerged as a major research paradigm in latter third of the 20th century. In a biting critique of Heron's paper by a young Ernst Rüdin, we see the beginnings of a long-running argument in psychiatric genetics about the relative value of detailed phenotyping versus novel statistical methods and of Mendelian versus Biometrical methods. While much interest has focused on the eugenic orientation of German psychiatric genetics in the early 20th century, these early British biometrical geneticists, like the majority of geneticists of that day, were also ardent advocates of the eugenic application of their research results.
Identifiants
pubmed: 34997802
doi: 10.1002/ajmg.b.32885
doi:
Types de publication
Historical Article
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6-15Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Cai, N., Revez, J. A., Adams, M. J., Andlauer, T. F. M., Breen, G., Byrne, E. M., … Flint, J. (2020). Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nature Genetics, 52(4), 437-447.
Diem, O. (1905). Die psycho-neurotische erbliche Belastung der Geistesgesunden und der Geisteskranken. Eine statistisch-kritische Untersuchung auf Grund eigener Beobachtungen. I. Teil. Archiv für Rassen- und Gesellschaftsbiologie, 2, 336-368.
Driver, E. D. (1956). Pioneers in Criminology XIV-Charles Buckman Goring (1870-1919). Journal of Criminal Law and Criminology, 47, 515.
Edwards, J. H. (1969). Familial predisposition in man. British Medical Bulletin, 25(1), 58-64.
Ekström, J. (2011). The phi-coefficient, the tetrachoric correlation coefficient, and the Pearson-Yule debate. Los Angeles, CA: UCLA Department of Statistics. Retrieved from https://escholarshiporg
Falconer, D. S. (1965). The inheritance of liability to certain diseases, estimated from the incidence among relatives. Annals of Human Genetics, 29, 51-76.
Fisher, R. A. (1918). On the correlation between relatives on the supposition of Mendelian inheritance. Transactions of the Royal Society of Edinburgh, 52, 399-433.
Goring, C. (1909). On the inheritance of the diathesis of phthisis and insanity; a statistical study based upon the family history of 1,500 criminals. In Drapers' company research memoirs; Department of Applied Mathematics UC, London. London, England: Dulau & Co..
Goring, C. (1913). The English convict: A statistical study. London, England: HMS.
Gottesman, I. I., & Bertelsen, A. (1996). Legacy of German psychiatric genetics: Hindsight is always 20/20. American Journal of Medical Genetics, 67(4), 317-322.
Heron, D. (1907). A first study of the statistics of insanity and the inheritance of the insane diathesis. London, England: Dulau & Co.
Jauregg, J. W. V. (1902). Ueber erbliche Belastung. Wiener klinische Wochenschrift, 15(44), 1153-1159.
Kendler, K. S. (2021). The prehistory of psychiatric genetics: 1780-1910. American Journal of Psychiatry, 178, 490-508.
Kendler, K. S., & Klee, A. (2020). The turn to controls and the refinement of the concept of hereditary burden: The 1895 study of Jenny Koller. American Journal of Medical Genettics. Part B, Neuropsychiatric Genetics, 183(7), 433-442.
Kendler, K. S., & Klee, A. (2021). Julius Wagner von Jauregg, Otto Diem and research methods for assessing the contributions of hereditary burden to mental illness risk: 1902-1906. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 186, 50-64.
Kendler, K. S., & Zerbin-Rudin, E. (1996). Abstract and review of “Zur Erbpathologie der Schizophrenie” (contribution to the genetics of schizophrenia). 1916. American Journal of Medical Genetics, 67(4), 343-346.
Kevles, D. J. (1985). In the name of eugenics: Genetics and the uses of human heredity. Berkeley/Los Angeles, CA: University of California Press.
Koller, J. (1895). Beitrag zur Erblichkeitsstatistik der Geisteskranken im Canton Zürich; Vergleichung derselben mit der erblichen Belastung gesunder Menschen durch Geistesstörungen u. dergl. Archiv für Psychiatrie und Nervenkrankheiten, 27(1), 268-294.
Mather, K., & Jinks, J. L. (1982). Biometrical genetics: The study of continuous variation (3rd ed.). London, England: Chapman & Hall.
Olby, R. C. (1985). Origins of Mendelism (2nd ed.). Chicago, IL: University of Chicago Press.
Pearson, E. (1970). David Heron, 1881-1969. Journal of the Royal Statistical Society, Series A, 133, 287-291.
Pearson, K. (1905). On the inheritance of insanity. British Medical Journal, 1(2317), 1175-1177.
Pearson, K. I. (1900). Mathematical contributions to the theory of evolution-VII. On the correlation of characters not quantitatively measurable. Philosophical Transactions of the Royal Society of London Series A, 195(262-273), 1-47.
Provine, W. B. (1987). The origins of theoretical population genetics. Chicago, IL: University of Chicago Press.
Rosanoff, A. J., & Orr, F. I. (1911). A study of heredity of insanity in the light of the Mendelian theory. Cold Springs Harbor, NY: Eugenics Records Office.
Rudin, E. (1908). Heron, David, a first study of the statistics of insanity and the inheritance of the insane diathesis. Archiv für Rassen- und Gesellschafts-Biologie, Einschliesslich Rassenund Gesellschafts-Hygiene, 5, 133-135.
Rüdin, E. (1911). Einige Wege und Ziele der Familienforschung, mit Rücksicht auf die Psychiatrie. Zeitschrift für die gesamte Neurologie und Psychiatrie, 7(1), 487-585.
Rudin, E. (1916). Studien uber Vererbung und entstehung geistiger Storungen. I. Zur vererbung und neuentstehung der dementia praecox (Studies on the inheritance and origin of mental illness. I. The problem of the inheritance and primary origin of dementia praecox). In Monographien aus dem Gesamtgebiet der Neurologie und Psychiatrie (Vol. 12). Berlin, Germany: Springer.
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003). Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies. Archives of General Psychiatry, 60(12), 1187-1192.
Teicher, A. (2020). Social Mendelism: Genetics and the politics of race in Germany, 1900-1948. Cambridge, England: Cambridge University Press.
Urquhart, A. (1907). On insanity, with special reference to heredity and prognosis. Journal of Mental Science, 53, 233-321.
Weinberg, W. (1903). Pathological inheritance and genealogical-clinical statistics. Deutsches Archiv fur klinische Medizin, 78, 521-540.
Weiss, S. F. (2010). The Nazi symbiosis: Human genetics and politics in the Third Reich. Chicago, IL: University of Chicago Press.
Wray, N. R., & Gottesman, I. I. (2012). Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Frontiers in Genetics, 3, 118.