Effect of whey protein consumption on IL-6 and TNF-α: A systematic review and meta-analysis of randomized controlled trials.
IL-6
Inflammation
Meta-analysis
TNF-α
Whey protein
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
09
11
2021
revised:
14
12
2021
accepted:
16
12
2021
pubmed:
9
1
2022
medline:
1
4
2022
entrez:
8
1
2022
Statut:
ppublish
Résumé
Due to inconsistent data about WP supplementation on inflammatory markers, present systematic review and meta-analysis was done to summarize its effect on TNF-α and IL-6. Our search was done in Pubmed, Scopus, Embase, and Cochrane up to June 2021. Weighted mean difference (WMD) and 95% confidence intervals (CI) was used to indicate the effect sizes. Conceivable sources of heterogeneity were detected by subgroup analysis. Overall, 11 eligible RCTs were included. The pooled results showed that WP supplementation had no significant effect on TNF-α and IL-6 status compare to those receiving carbohydrate and other types of proteins as placebo. Results from subgroup analysis based on health status, study duration, WP dosage and sex, expressed no favorable effect of WP on TNF-α and IL-6 levels. It can be concluded that whey supplementation had no favorable effects on inflammatory biomarkers including TNF- α and IL-6.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Due to inconsistent data about WP supplementation on inflammatory markers, present systematic review and meta-analysis was done to summarize its effect on TNF-α and IL-6.
METHODS
METHODS
Our search was done in Pubmed, Scopus, Embase, and Cochrane up to June 2021. Weighted mean difference (WMD) and 95% confidence intervals (CI) was used to indicate the effect sizes. Conceivable sources of heterogeneity were detected by subgroup analysis.
RESULTS
RESULTS
Overall, 11 eligible RCTs were included. The pooled results showed that WP supplementation had no significant effect on TNF-α and IL-6 status compare to those receiving carbohydrate and other types of proteins as placebo. Results from subgroup analysis based on health status, study duration, WP dosage and sex, expressed no favorable effect of WP on TNF-α and IL-6 levels.
CONCLUSION
CONCLUSIONS
It can be concluded that whey supplementation had no favorable effects on inflammatory biomarkers including TNF- α and IL-6.
Identifiants
pubmed: 34998259
pii: S1871-4021(21)00392-1
doi: 10.1016/j.dsx.2021.102372
pii:
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Whey Proteins
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102372Informations de copyright
Copyright © 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest No conflict of interest declared.