Stir bar sorptive-dispersive microextraction by a poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent for the determination of tricyclic antidepressants and their main active metabolites in human urine.
Active metabolites
Human urine
Magnetic nanoparticles
Polymeric sorbent
Stir bar sorptive-dispersive microextraction
Tricyclic antidepressants
Journal
Mikrochimica acta
ISSN: 1436-5073
Titre abrégé: Mikrochim Acta
Pays: Austria
ID NLM: 7808782
Informations de publication
Date de publication:
08 01 2022
08 01 2022
Historique:
received:
08
10
2021
accepted:
20
12
2021
entrez:
9
1
2022
pubmed:
10
1
2022
medline:
22
3
2022
Statut:
epublish
Résumé
A poly(methacrylic acid-co-ethylene glycol dimethacrylate)-based magnetic sorbent was used for the rapid and sensitive determination of tricyclic antidepressants and their main active metabolites in human urine. This material was characterized by magnetism measurements, zeta potential, scanning electron microscopy, nitrogen adsorption-desorption isotherms, and thermogravimetric analysis. The proposed analytical method is based on stir bar sorptive-dispersive microextraction (SBSDME) followed by liquid chromatography-tandem mass spectrometry. The main parameters involved in the extraction step were optimized by using the response surface methodology as a multivariate optimization method, whereas a univariate approach was employed to study the desorption parameters. Under the optimized conditions, the proposed method was properly validated showing good linearity (at least up to 50 ng mL
Identifiants
pubmed: 35000010
doi: 10.1007/s00604-021-05156-7
pii: 10.1007/s00604-021-05156-7
pmc: PMC8742809
doi:
Substances chimiques
Antidepressive Agents, Tricyclic
0
Cobalt
3G0H8C9362
cobalt ferrite
0
Ferric Compounds
0
poly((ethylene glycol dimethacrylate)-co-(methacrylic acid))
0
Polymethacrylic Acids
0
Silicon Dioxide
7631-86-9
poly(methacrylic acid-ethylene glycol dimethacrylate)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
52Subventions
Organisme : Spanish Ministry of Science and Innovation
ID : PID2020-118924RB-I00
Informations de copyright
© 2022. The Author(s).
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