The urinary exosomes derived from premature infants attenuate cisplatin-induced acute kidney injury in mice via microRNA-30a-5p/ mitogen-activated protein kinase 8 (MAPK8).
Animals
Cell Line
Chemical and Drug Induced Liver Injury
/ blood
Cisplatin
/ adverse effects
Creatinine
/ blood
Disease Models, Animal
Down-Regulation
Exosomes
/ genetics
Female
HEK293 Cells
Humans
Infant, Newborn
Infant, Premature
/ urine
Mice
Mice, Inbred C57BL
MicroRNAs
/ genetics
Mitogen-Activated Protein Kinase 8
/ genetics
Urinary exosomes
acute kidney injury
microRNA-30a-5p
mitogen-activated protein kinase 8
Journal
Bioengineered
ISSN: 2165-5987
Titre abrégé: Bioengineered
Pays: United States
ID NLM: 101581063
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
22
2
2022
Statut:
ppublish
Résumé
Acute kidney injury (AKI) is a susceptible factor for chronic kidney disease (CKD). There is still a lack of effective prevention methods in clinical practice. This study investigated the protective effect of the urinary exosomes from premature infants on cisplatin-induced acute kidney injury. Here we isolated exosomes from the fresh urine of premature infants. A C57BL/6 mice model of cisplatin-induced acute kidney injury was given 100 ug urinary exosomes 24 hours after model establishment. The kidneys were collected for pathological examination and the evaluation of renal tubular damage and apoptosis. In the
Identifiants
pubmed: 35001794
doi: 10.1080/21655979.2021.2021686
pmc: PMC8805886
doi:
Substances chimiques
MIRN30a microRNA, human
0
MicroRNAs
0
Creatinine
AYI8EX34EU
Mitogen-Activated Protein Kinase 8
EC 2.7.11.24
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1650-1665Références
J Am Soc Nephrol. 2017 Oct;28(10):2985-2992
pubmed: 28663230
Theranostics. 2020 Jul 25;10(21):9561-9578
pubmed: 32863945
Stem Cell Res Ther. 2016 Feb 06;7:24
pubmed: 26852014
Lancet. 2013 Jul 13;382(9887):170-9
pubmed: 23727171
Nat Rev Nephrol. 2020 Apr;16(4):193-205
pubmed: 32051567
Nat Rev Nephrol. 2019 Apr;15(4):220-239
pubmed: 30651611
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
J Am Soc Nephrol. 2021 Feb;32(2):323-341
pubmed: 33478972
Kidney Int. 2020 Jun;97(6):1181-1195
pubmed: 32139089
Front Cell Dev Biol. 2020 Mar 24;8:188
pubmed: 32266268
J Appl Toxicol. 2005 Sep-Oct;25(5):374-82
pubmed: 16013042
Sci Rep. 2021 Apr 28;11(1):9165
pubmed: 33911095
Tissue Eng Part A. 2017 Nov;23(21-22):1262-1273
pubmed: 28471327
Cell Death Differ. 2020 Jan;27(1):210-226
pubmed: 31097789
Biomark Res. 2019 Apr 4;7:8
pubmed: 30992990
Life Sci. 2021 Jul 15;277:119458
pubmed: 33831424
Int J Proteomics. 2012;2012:971907
pubmed: 22852084
J Am Coll Cardiol. 2016 Dec 13;68(23):2577-2584
pubmed: 27931616
Int J Mol Sci. 2019 Jun 20;20(12):
pubmed: 31226747
Kidney Int. 2018 Jan;93(1):27-40
pubmed: 29291820
Sci Rep. 2017 Jan 17;7:40601
pubmed: 28094285
J Clin Invest. 1984 Oct;74(4):1156-64
pubmed: 6434591
Stem Cell Res Ther. 2017 Dec 04;8(1):273
pubmed: 29202871
Cell Death Dis. 2018 Nov 13;9(11):1126
pubmed: 30425237
Lancet. 2020 May 9;395(10235):1465-1467
pubmed: 32334653
J Cell Mol Med. 2021 Dec;25(23):10798-10813
pubmed: 31568645
Nephrol Dial Transplant. 2011 May;26(5):1474-83
pubmed: 21324974
Kidney Int. 2012 Mar;81(5):442-8
pubmed: 22113526
Molecules. 2020 Nov 30;25(23):
pubmed: 33266089
Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1545-52
pubmed: 25107948
Curr Opin Crit Care. 2016 Dec;22(6):513-519
pubmed: 27763922
Stem Cells Transl Med. 2019 Jan;8(1):82-92
pubmed: 30302937
Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1207-1216
pubmed: 28285987
Mol Ther. 2020 Feb 5;28(2):490-502
pubmed: 31818691
Clin Biochem. 2020 Oct;84:79-86
pubmed: 32673627
Semin Dial. 2018 Sep;31(5):519-527
pubmed: 29738093
Nat Med. 2010 May;16(5):535-43, 1p following 143
pubmed: 20436483