Proteogenomics for pediatric brain cancer.
Brain cancer
Proteogenomics
Targeted therapy
Journal
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
ISSN: 0327-9545
Titre abrégé: Biocell
Pays: United States
ID NLM: 9438655
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
11
1
2022
Statut:
ppublish
Résumé
Pediatric central nervous system tumors are the most common tumors in children, it constitute 15%-20% of all malignancies in children and are the leading cause of cancer related deaths in children. Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes. Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.
Types de publication
Journal Article
Langues
eng
Pagination
1459-1463Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: The author declares that there are no conflicts of interest to report regarding the present study.
Références
Cancers (Basel). 2020 Jun 11;12(6):
pubmed: 32545204
J Proteomics Bioinform. 2016;9(2):53-57
pubmed: 27019568
Cell. 2020 Dec 23;183(7):1962-1985.e31
pubmed: 33242424
Cell. 2016 Jul 28;166(3):755-765
pubmed: 27372738
Nature. 2017 Jul 19;547(7663):311-317
pubmed: 28726821
Nature. 2018 Mar 15;555(7696):321-327
pubmed: 29489754
Cell. 2019 May 2;177(4):1035-1049.e19
pubmed: 31031003
Cancer. 2018 Nov 1;124(21):4168-4180
pubmed: 30255939
Science. 2019 Mar 15;363(6432):1170-1175
pubmed: 30872516
J Clin Oncol. 2006 Jul 20;24(21):3431-7
pubmed: 16849758
Clin Proteomics. 2017 May 16;14:17
pubmed: 28522939
Genome Med. 2017 Apr 19;9(1):34
pubmed: 28420421
Nature. 2018 Mar 22;555(7697):469-474
pubmed: 29539639
Cell. 2019 Oct 3;179(2):561-577.e22
pubmed: 31585088
Cancer Med. 2019 Jan;8(1):40-50
pubmed: 30569607
Cell. 2019 Oct 31;179(4):964-983.e31
pubmed: 31675502
Cell. 2020 Feb 20;180(4):729-748.e26
pubmed: 32059776
Cell. 2020 Jul 9;182(1):200-225.e35
pubmed: 32649874
Cell. 2020 Nov 25;183(5):1436-1456.e31
pubmed: 33212010