Integrated Lymphopenia Analysis in Younger and Older Patients With Multiple Sclerosis Treated With Cladribine Tablets.

Cladribine tablets (CladT) preferentially reduce B and T lymphocyte levels. As aging is associated with a decline in immune function, the effect of CladT on lymphocyte levels may differ by age. This

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Copyright © 2021 Giovannoni, Coyle, Vermersch, Walker, Aldridge, Nolting, Galazka, Lemieux and Leist.

Déclaration de conflit d'intérêts

The authors declare that this study received funding from EMD Serono, Inc., Rockland, MA, USA, an affiliate of Merck KGaA (CrossRef Funder ID: 10.13039/100004755). The funder had the following involvement with the study: designing the study, collecting and analyzing the data. The authors had full control of the manuscript and provided their final approval of all content. GG has received speaker honoraria and consulting fees from Abbvie, Actelion, Atara Bio, Almirall, Bayer Schering Pharma, Biogen Idec, Celgene-BMS, FivePrime, GlaxoSmithKline, GW Pharma, Janssen, Merck & Co., Merck Healthcare KGaA, Darmstadt, Germany, Pfizer Inc, Protein Discovery Laboratories, Teva Pharmaceutical Industries Ltd, Sanofi-Genzyme, UCB, Vertex Pharmaceuticals, Ironwood, and Novartis; and research support unrelated to this study from Biogen Idec, Merck & Co., Novartis, and Ironwood. PKC declares being an advisor or consultant for Accordant, Biogen, Bristol Myers Squibb, Celgene, Genentech/Roche, Genzyme/Sanofi, GlaxoSmithKline, Janssen, Mylan, Novartis, and Viela Bio, and receiving grants for clinical research from Actelion, Alkermes, Celgene, Corrona LLC, Genentech/Roche, MedDay, NINDS, and Novartis. PV has received honoraria or consulting fees from Biogen, Sanofi-Genzyme, Novartis, Merck Healthcare KGaA, Darmstadt, Germany, Celgene, Roche, AB Science, and Imcyse; and research support from Biogen, Sanofi-Genzyme, and Merck Healthcare KGaA, Darmstadt, Germany. BW has received consulting fees from Biogen, Celgene, EMD Serono, Inc., Rockland, MA, USA, an affiliate of Merck KGaA, Novartis, and Sanofi-Genzyme. JA is an employee of EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA. AN is an employee of Merck Healthcare KGaA, Darmstadt, Germany. AG was employed by Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA at the time of the study. He is now a consultant for Merck Healthcare KGaA, Darmstadt, Germany. CL is an employee of EMD Inc. Mississauga, Ontario, Canada, an affiliate of Merck KGaA. TPL received consultancy fees or clinical research grants from Acorda, Bayer, Biogen, Daiichi, EMD Serono, Inc., Rockland, MA, USA, an affiliate of Merck KGaA, Darmstadt, Germany, Novartis, ONO, Pfizer and Teva Neuroscience.