Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β
Erythroid
Fetal hemoglobin
LSD1
RN-1
Thalassemia
Journal
Hematology reports
ISSN: 2038-8322
Titre abrégé: Hematol Rep
Pays: Switzerland
ID NLM: 101556723
Informations de publication
Date de publication:
26 Nov 2021
26 Nov 2021
Historique:
received:
26
04
2021
accepted:
13
10
2021
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
11
1
2022
Statut:
epublish
Résumé
Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-thalassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultured human erythroid cells. Here, the HbF-inducing activity of RN-1 was investigated in erythroid progenitor cells derived from β
Identifiants
pubmed: 35003571
doi: 10.4081/hr.2021.9215
pmc: PMC8672213
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9215Informations de copyright
©Copyright: the Author(s).
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare no potential conflict of interest.
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