Opioid Receptor-Mediated and Non-Opioid Receptor-Mediated Roles of Opioids in Tumour Growth and Metastasis.
OGFr
TLR4
cancer
metastasis
opioid antagonist
opioid receptor
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
10
2021
accepted:
06
12
2021
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
11
1
2022
Statut:
epublish
Résumé
Opioids are administered to cancer patients in the period surrounding tumour excision, and in the management of cancer-associated pain. The effects of opioids on tumour growth and metastasis, and their consequences on disease outcome, continue to be the object of polarised, discrepant literature. It is becoming clear that opioids contribute a range of direct and indirect effects to the biology of solid tumours, to the anticancer immune response, inflammation, angiogenesis and importantly, to the tumour-promoting effects of pain. A common misconception in the literature is that the effect of opioid agonists equates the effect of the mu-opioid receptor, the major target of the analgesic effect of this class of drugs. We review the evidence on opioid receptor expression in cancer, opioid receptor polymorphisms and cancer outcome, the effect of opioid antagonists, especially the peripheral antagonist methylnaltrexone, and lastly, the evidence available of a role for opioids through non-opioid receptor mediated actions.
Identifiants
pubmed: 35004315
doi: 10.3389/fonc.2021.792290
pmc: PMC8732362
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
792290Informations de copyright
Copyright © 2021 Scroope, Singleton, Hollmann and Parat.
Déclaration de conflit d'intérêts
MH has received research funding from CSL Behring, ZonMw, the Society of Cardiovasular Anesthesiologists (SCA) and the European Association of Cardiothoracic Anaesthesiology (EACTA); and has received compensation from Eurocept Pharmaceuticals BV and IDD for service as a consultant. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cancer Res. 2011 Oct 1;71(19):6282-91
pubmed: 21835894
Eur J Pharmacol. 2002 Apr 26;441(3):185-91
pubmed: 12063091
J Voice. 2021 Mar 7;:
pubmed: 33750623
Curr Pharm Des. 2019;25(28):3020-3027
pubmed: 31269880
Anesthesiology. 2012 Apr;116(4):857-67
pubmed: 22343475
Science. 1983 Aug 12;221(4611):671-3
pubmed: 6867737
J Surg Oncol. 2009 Dec 15;100(8):725-31
pubmed: 19722233
Tumori. 1993 Jun 30;79(3):198-201
pubmed: 8236504
PLoS One. 2014 Mar 24;9(3):e91577
pubmed: 24662916
Br J Anaesth. 2014 Jul;113 Suppl 1:i103-8
pubmed: 24920011
Cancers (Basel). 2021 Oct 21;13(21):
pubmed: 34771442
PLoS One. 2015 Apr 08;10(4):e0123407
pubmed: 25853862
Clin Transl Oncol. 2019 Jun;21(6):695-701
pubmed: 30470993
Contemp Clin Trials. 2008 Jul;29(4):517-26
pubmed: 18291727
Clin J Pain. 2019 Jan;35(1):77-86
pubmed: 30028366
Int J Med Sci. 2020 Oct 18;17(18):2941-2946
pubmed: 33173414
J Nucl Med. 2007 Feb;48(2):207-13
pubmed: 17268016
J Hematol. 2020 Sep;9(3):41-54
pubmed: 32855752
Cancer. 2013 Dec 1;119(23):4103-10
pubmed: 24104703
Int Immunopharmacol. 2021 Oct;99:107713
pubmed: 34426103
Int J Cancer. 2016 Apr 1;138(7):1754-64
pubmed: 26453448
Peptides. 1980 Winter;1(4):309-13
pubmed: 6272240
Int Immunopharmacol. 2020 Jan;78:106068
pubmed: 31835085
Brain Res Bull. 1981 Jul;7(1):25-32
pubmed: 7272785
Brain Behav Immun. 2017 Mar;61:244-258
pubmed: 27939249
Asian Pac J Cancer Prev. 2021 Feb 01;22(2):633-640
pubmed: 33639684
Life Sci. 1981 Mar 9;28(10):1095-102
pubmed: 7231040
Anesthesiology. 2021 Aug 1;135(2):233-245
pubmed: 34195784
Anesth Analg. 2011 Dec;113(6):1353-64
pubmed: 22003224
Sci Rep. 2016 Aug 12;6:31572
pubmed: 27514308
Cancer Gene Ther. 2021 Feb;28(1-2):18-26
pubmed: 32595215
Biochem Pharmacol. 2012 Sep 15;84(6):746-55
pubmed: 22687282
Brain Behav Immun. 2010 Jan;24(1):83-95
pubmed: 19679181
Oncol Rep. 2016 Nov;36(5):2579-2586
pubmed: 27665747
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jan;306(1):93-6
pubmed: 424002
PLoS One. 2013;8(2):e56540
pubmed: 23437162
Int J Clin Oncol. 2013 Aug;18(4):666-9
pubmed: 22752309
Anticancer Res. 1996 Jul-Aug;16(4A):1893-8
pubmed: 8712718
Postgrad Med. 2016;128(3):282-9
pubmed: 26839023
J Angiogenes Res. 2010 Feb 19;2(1):5
pubmed: 20298531
Microvasc Res. 2006 Jul-Sep;72(1-2):3-11
pubmed: 16820176
Front Oncol. 2021 Jun 18;11:686877
pubmed: 34222012
Eur J Pharmacol. 1978 Sep 15;51(2):185-6
pubmed: 212280
Brain Res. 1982 Aug 12;245(2):285-92
pubmed: 6289965
Tumour Biol. 2015 Jun;36(6):4655-60
pubmed: 25618602
Cancer Res. 1996 Apr 1;56(7):1695-701
pubmed: 8603422
Cancer Metastasis Rev. 2011 Jun;30(2):225-38
pubmed: 21267766
Int Immunopharmacol. 2020 Sep;86:106718
pubmed: 32585612
Lancet. 2019 Nov 16;394(10211):1807-1815
pubmed: 31645288
Int J Mol Med. 2007 Mar;19(3):421-8
pubmed: 17273790
Pharmacol Res. 2020 Sep;159:104938
pubmed: 32504831
Br J Anaesth. 2021 Feb;126(2):367-376
pubmed: 33220939
Nat Med. 2007 Sep;13(9):1050-9
pubmed: 17704786
Cancer Lett. 2006 Apr 8;235(1):75-83
pubmed: 15922507
Anesthesiology. 2012 Apr;116(4):896-902
pubmed: 22433205
Sci Rep. 2015 Jun 16;5:11389
pubmed: 26078009
Br J Pharmacol. 2013 Mar;168(6):1421-9
pubmed: 23083095
J Breast Cancer. 2016 Jun;19(2):206-9
pubmed: 27382398
Clin Transl Oncol. 2018 Jul;20(7):808-814
pubmed: 29127594
Anesth Analg. 2011 Mar;112(3):558-67
pubmed: 21156980
J Cell Physiol. 2021 Nov;236(11):7698-7710
pubmed: 34038587
Cancer Lett. 1983 Nov;21(1):89-94
pubmed: 6640516
Biochem Biophys Res Commun. 1991 Mar 15;175(2):625-30
pubmed: 1850249
Pharmacol Biochem Behav. 2014 Aug;123:25-33
pubmed: 24201053
Hum Pathol. 2013 Sep;44(9):1756-65
pubmed: 23574786
Mol Cancer Ther. 2008 Jun;7(6):1669-79
pubmed: 18566238
Br J Pharmacol. 2015 Jan;172(2):251-9
pubmed: 24467261
Ann Oncol. 2016 Nov;27(11):2032-2038
pubmed: 27573565
Int J Oncol. 2006 Aug;29(2):489-94
pubmed: 16820893
Nat Rev Clin Oncol. 2015 Apr;12(4):213-26
pubmed: 25601442
Pain. 2001 Feb 1;90(1-2):191-9
pubmed: 11166986
Alcohol Clin Exp Res. 2016 Jan;40(1):134-40
pubmed: 26727531
Pain. 2015 Oct;156(10):1835-1844
pubmed: 26181303
Br J Anaesth. 2021 Jul;127(1):75-84
pubmed: 34147159
Int J Oncol. 2013 Oct;43(4):1281-90
pubmed: 23903826
Anticancer Res. 1998 May-Jun;18(3A):1787-92
pubmed: 9673405
Br J Anaesth. 2020 Nov;125(5):722-729
pubmed: 32900505
J Clin Lab Anal. 2017 Jan;31(1):
pubmed: 27373278
Exp Dermatol. 2011 Jan;20(1):24-8
pubmed: 20955200
PLoS One. 2018 Oct 4;13(10):e0204830
pubmed: 30286124
BMJ. 2011 Mar 29;342:d1491
pubmed: 21447587
Fundam Clin Pharmacol. 2021 Feb;35(1):174-183
pubmed: 32564393
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11234-8
pubmed: 1333602