Impact of Pregnancy on GFR Decline and Kidney Histology in Kidney Transplant Recipients.
allograft
glomerular filtration rate
histology
kidney transplant
pregnancy
vascular injury
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
02
06
2021
revised:
11
10
2021
accepted:
12
10
2021
entrez:
10
1
2022
pubmed:
11
1
2022
medline:
11
1
2022
Statut:
epublish
Résumé
Women with advanced kidney disease are advised to wait until after transplant to pursue pregnancy, but the impact of pregnancy on estimated glomerular filtration rate (eGFR) decline and kidney histology is unclear. We identified a cohort of women aged 18 to 44 years at transplant from 1996 to 2014 at our 3-site program ( There were 37 women with one or more pregnancies lasting longer than 20 weeks gestation post-transplant. Comparing women with and without pregnancy post-transplant, there was a significant increase in the rate of eGFR decline after pregnancy (-2.4 ml/min per 1.73 m Pregnancy affects the rate of eGFR decline in the allograft. Postpregnancy biopsy findings revealed an increase in vascular injury, which could be a potential mechanism. We did not find a significant increase in risk of graft failure or reduction in eGFR by 50% owing to pregnancy.
Identifiants
pubmed: 35005311
doi: 10.1016/j.ekir.2021.10.010
pii: S2468-0249(21)01469-8
pmc: PMC8720805
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28-35Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002377
Pays : United States
Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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