The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients.
Dry-mouth
Dry-mouth interventions
Salivary flow rate
Sjögren’s syndrome
Xerostomia
Xerostomia Inventory
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
06
09
2021
accepted:
10
11
2021
pubmed:
11
1
2022
medline:
9
3
2022
entrez:
10
1
2022
Statut:
ppublish
Résumé
Dry-mouth patients use different interventions to relieve their oral dryness. As recent studies showed that various subgroups of dry-mouth patients perceived different intra-oral regions as most dry, the present study investigated whether the use of dry-mouth interventions by various subgroups of dry-mouth patients was related to the perceived oral dryness as well as salivary flow rate. Xerostomia Inventory (XI) scores, Regional Oral Dryness Score (RODI) scores and used dry-mouth interventions were extracted from the medical records of 528 patients visiting a saliva clinic. Based on their medical history, they were allocated into 6 subgroups. The subgroups of dry-mouth patients used a wide range of interventions to relieve their oral dryness. Sjögren's syndrome patients used most interventions more frequently than patients with oral dryness due to use of a limited number of medications and controls. Patients using medications showed associations between the total XI score and dry-mouth interventions aimed at the entire mouth. In medication using patients and controls, the locally applied intervention "using mouth gel" was associated with RODI scores of the anterior tongue. The use of dry-mouth interventions was associated with dry-mouth feelings. Use of interventions aimed to relieve dryness of the entire mouth was significantly associated with total XI score, while locally applied interventions were significantly associated with the severity of dryness at specific intra-oral regions, the anterior tongue in particular. The results will help clinicians to advise dry-mouth patients about the most suitable interventions for relief of oral dryness complaints.
Identifiants
pubmed: 35006295
doi: 10.1007/s00784-021-04292-x
pii: 10.1007/s00784-021-04292-x
doi:
Substances chimiques
Gels
0
Types de publication
Journal Article
Langues
eng
Pagination
3097-3108Subventions
Organisme : NTVT
ID : grant number OZB2018.01
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Saleh J, Figueiredo MA, Cherubini K, Salum FG (2015) Salivary hypofunction: an update on aetiology, diagnosis and therapeutics. Arch Oral Biol 60(2):242–255. https://doi.org/10.1016/j.archoralbio.2014.10.004
doi: 10.1016/j.archoralbio.2014.10.004
pubmed: 25463902
Ying Joanna ND, Thomson WM (2015) Dry mouth - an overview. Singapore Dent J 36:12–17. https://doi.org/10.1016/j.sdj.2014.12.001
doi: 10.1016/j.sdj.2014.12.001
pubmed: 26684490
Porter SR, Scully C, Hegarty AM (2004) An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97(1):28–46. https://doi.org/10.1016/j.tripleo.2003.07.010
doi: 10.1016/j.tripleo.2003.07.010
pubmed: 14716254
Tanasiewicz M, Hildebrandt T, Obersztyn I (2016) Xerostomia of various etiologies: a review of the literature. Adv Clin Exp Med 25(1):199–206. https://doi.org/10.17219/acem/29375
doi: 10.17219/acem/29375
pubmed: 26935515
Al Hamad A, Lodi G, Porter S, Fedele S, Mercadante V (2019) Interventions for dry mouth and hyposalivation in Sjögren’s syndrome: a systematic review and meta-analysis. Oral Dis 25(4):1027–1047. https://doi.org/10.1111/odi.12952
doi: 10.1111/odi.12952
pubmed: 30086205
Furness S, Bryan G, McMillan R, Worthington HV (2013) Interventions for the management of dry mouth: non-pharmacological interventions. Cochrane Database Syst Rev (8):Cd009603. https://doi.org/10.1002/14651858.CD009603.pub2
Furness S, Worthington HV, Bryan G, Birchenough S, McMillan R (2011) Interventions for the management of dry mouth: topical therapies. Cochrane Database Syst Rev (12):Cd008934. https://doi.org/10.1002/14651858.CD008934.pub2
Thomson WM, Chalmers JM, Spencer AJ, Williams SM (1999) The Xerostomia Inventory: a multi-item approach to measuring dry mouth. Community Dent Health 16(1):12–17
pubmed: 10697349
Assy Z, Jager DHJ, Mashhour E, Bikker FJ, Brand HS (2020) Regional differences in perceived oral dryness as determined with a newly developed questionnaire, the Regional Oral Dryness Inventory. Clin Oral Investig. https://doi.org/10.1007/s00784-020-03276-7
doi: 10.1007/s00784-020-03276-7
pubmed: 32382921
pmcid: 7544722
Assy Z, Bots CP, Arisoy HZ, Gülveren SS, Bikker FJ, Brand HS (2021) Differences in perceived intra-oral dryness in various dry-mouth patients as determined using the Regional Oral Dryness Inventory. Clin Oral Investig 25(6):4031–4043. https://doi.org/10.1007/s00784-020-03734-2
doi: 10.1007/s00784-020-03734-2
pubmed: 33496869
pmcid: 8137633
Navazesh M, Kumar SK (2008) Measuring salivary flow: challenges and opportunities. J Am Dent Assoc 139 Suppl:35s-40s. https://doi.org/10.14219/jada.archive.2008.0353
Kalk WW, Vissink A, Spijkervet FK, Bootsma H, Kallenberg CG, Nieuw Amerongen AV (2001) Sialometry and sialochemistry: diagnostic tools for Sjogren’s syndrome. Ann Rheum Dis 60(12):1110–1116. https://doi.org/10.1136/ard.60.12.1110
doi: 10.1136/ard.60.12.1110
pubmed: 11709452
pmcid: 1753437
Dawes C (1972) Circadian rhythms in human salivary flow rate and composition. J Physiol 220(3):529–545. https://doi.org/10.1113/jphysiol.1972.sp009721
doi: 10.1113/jphysiol.1972.sp009721
pubmed: 5016036
pmcid: 1331668
Smeets EC, de Jong KJ, Abraham-Inpijn L (1998) Detecting the medically compromised patient in dentistry by means of the medical risk-related history. A survey of 29,424 dental patients in The Netherlands. Prev Med 27(4):530–535. https://doi.org/10.1006/pmed.1998.0285
doi: 10.1006/pmed.1998.0285
pubmed: 9672946
Abraham-Inpijn L, Russell G, Abraham DA, Backman N, Baum E, Bullon-Fernandez P, Declerck D, Fricain JC, Georgelin M, Karlsson KO, Lamey PJ, Link-Tsatsouli I, Rigo O (2008) A patient-administered Medical Risk Related History questionnaire (EMRRH) for use in 10 European countries (multicenter trial). Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(5):597–605. https://doi.org/10.1016/j.tripleo.2007.09.032
doi: 10.1016/j.tripleo.2007.09.032
pubmed: 18299219
Brand HS, Bots CP, Veerman ECI (2011) Therapies for xerostomia in Sjögren’s disease are age- and gender-dependent. J Dent Res 90 (Special Issue A):1347
Assy Z, Bikker FJ, Picauly O, Brand HS (2021) The association between oral dryness and use of dry-mouth interventions in Sjögren’s syndrome patients. Clin Oral Investig. https://doi.org/10.1007/s00784-021-04120-2
doi: 10.1007/s00784-021-04120-2
pubmed: 34591182
pmcid: 8816756
Marcoulides KM, Raykov T (2019) Evaluation of variance inflation factors in regression models using latent variable modeling methods. Educ Psychol Meas 79(5):874–882. https://doi.org/10.1177/0013164418817803
doi: 10.1177/0013164418817803
pubmed: 31488917
Kim JH (2019) Multicollinearity and misleading statistical results. Korean J Anesthesiol 72(6):558–569. https://doi.org/10.4097/kja.19087
doi: 10.4097/kja.19087
pubmed: 31304696
pmcid: 6900425
Brand HS, Ouzzine R, Bots CP (2013) Sticky saliva products. Br Dent J 214(3):95. https://doi.org/10.1038/sj.bdj.2013.118
doi: 10.1038/sj.bdj.2013.118
pubmed: 23392009
Gil-Montoya JA, Silvestre FJ, Barrios R, Silvestre-Rangil J (2016) Treatment of xerostomia and hyposalivation in the elderly: a systematic review. Med Oral Patol Oral Cir Bucal 21(3):e355-366. https://doi.org/10.4317/medoral.20969
doi: 10.4317/medoral.20969
pubmed: 27031061
pmcid: 4867210
Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M (2019) Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren’s syndrome. RMD Open 5(2):e001064. https://doi.org/10.1136/rmdopen-2019-001064
doi: 10.1136/rmdopen-2019-001064
pubmed: 31749986
pmcid: 6827762
Sasportas LS, Hosford DN, Sodini MA, Waters DJ, Zambricki EA, Barral JK, Graves EE, Brinton TJ, Yock PG, Le QT, Sirjani D (2013) Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol 116(1):e37-51. https://doi.org/10.1016/j.oooo.2013.02.017
doi: 10.1016/j.oooo.2013.02.017
pubmed: 23643579
pmcid: 4018820
Assy Z, Brand HS (2018) A systematic review of the effects of acupuncture on xerostomia and hyposalivation. BMC Complement Altern Med 18(1):57. https://doi.org/10.1186/s12906-018-2124-x
doi: 10.1186/s12906-018-2124-x
pubmed: 29439690
pmcid: 5811978
Ni X, Tian T, Chen D, Liu L, Li X, Li F, Liang F, Zhao L (2020) Acupuncture for radiation-induced xerostomia in cancer patients: a systematic review and meta-analysis. Integr Cancer Ther 19:1534735420980825. https://doi.org/10.1177/1534735420980825
doi: 10.1177/1534735420980825
pubmed: 33307864
pmcid: 7739209
Jose A, Singh ML, Magnuson B, Farag A, Varghese R, Papas A (2018) A randomized controlled study to evaluate an experimental moisturizing mouthwash formulation in participants experiencing dry mouth symptoms. Oral Surg Oral Med Oral Pathol Oral Radiol 126(3):231-239.e235. https://doi.org/10.1016/j.oooo.2018.05.007
doi: 10.1016/j.oooo.2018.05.007
pubmed: 29941402
Purdie J, Carpenter MD, Noll JJ, Stephens C, Taylor YJ, Napenas JJ, Brennan MT (2021) Xerostomia symptoms and treatment strategies associated with salivary flows. Oral Surg Oral Med Oral Pathol Oral Radiol 131(4):e116. https://doi.org/10.1016/j.oooo.2020.10.047
doi: 10.1016/j.oooo.2020.10.047
Carpenter GH (2013) The secretion, components, and properties of saliva. Annu Rev Food Sci Technol 4:267–276. https://doi.org/10.1146/annurev-food-030212-182700
doi: 10.1146/annurev-food-030212-182700
pubmed: 23464573
Roblegg E, Coughran A, Sirjani D (2019) Saliva: an all-rounder of our body. Eur J Pharm Biopharm 142:133–141. https://doi.org/10.1016/j.ejpb.2019.06.016
doi: 10.1016/j.ejpb.2019.06.016
pubmed: 31220573
Gravenmade EJ, Vissink A (1992) Management of the oral features of Sjögren’s syndrome. Neth J Med 40(3–4):117–124
pubmed: 1603201
Alves MB, Motta AC, Messina WC, Migliari DA (2004) Saliva substitute in xerostomic patients with primary Sjögren’s syndrome: a single-blind trial. Quintessence Int 35(5):392–396
pubmed: 15130080
Kho HS (2014) Understanding of xerostomia and strategies for the development of artificial saliva. Chin J Dent Res 17(2):75–83
pubmed: 25531014
Chaudhury NM, Shirlaw P, Pramanik R, Carpenter GH, Proctor GB (2015) Changes in saliva rheological properties and mucin glycosylation in dry mouth. J Dent Res 94(12):1660–1667. https://doi.org/10.1177/0022034515609070
doi: 10.1177/0022034515609070
pubmed: 26446936
Fox PC, Busch KA, Baum BJ (1987) Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 115(4):581–584. https://doi.org/10.1016/s0002-8177(87)54012-0
doi: 10.1016/s0002-8177(87)54012-0
pubmed: 3477595
Ito K, Takamatsu K, Nohno K, Sugano A, Funayama S, Katsura K, Kaneko N, Ogawa M, Meurman JH, Inoue M (2017) Factors associated with mucosal dryness in multiple regions and skin: a web-based study in women. J Obstet Gynaecol Res 43(5):880–886. https://doi.org/10.1111/jog.13290
doi: 10.1111/jog.13290
pubmed: 28422418
Gholami N, Hosseini Sabzvari B, Razzaghi A, Salah S (2017) Effect of stress, anxiety and depression on unstimulated salivary flow rate and xerostomia. Journal of dental research, dental clinics, dental prospects 11(4):247–252. https://doi.org/10.15171/joddd.2017.043
doi: 10.15171/joddd.2017.043
pubmed: 29354252
pmcid: 5768958
Humphrey SP, Williamson RT (2001) A review of saliva: normal composition, flow, and function. J Prosthet Dent 85(2):162–169. https://doi.org/10.1067/mpr.2001.113778
doi: 10.1067/mpr.2001.113778
pubmed: 11208206
de Jong KJ, Abraham-Inpijn L, Vinckier F, Declerck D (1997) The validity of a medical risk-related history for dental patients in Belgium. Int Dent J 47(1):16–20. https://doi.org/10.1111/j.1875-595x.1997.tb00672.x
doi: 10.1111/j.1875-595x.1997.tb00672.x
pubmed: 9448784
de Jong KJ, Borgmeijer-Hoelen A, Abraham-Inpijn L (1991) Validity of a risk-related patient-administered medical questionnaire for dental patients. Oral Surg Oral Med Oral Pathol 72(5):527–533. https://doi.org/10.1016/0030-4220(91)90488-x
doi: 10.1016/0030-4220(91)90488-x
pubmed: 1745509