Preclinical Pharmacokinetics of GZK-111, a Dipeptide with Neuroprotective Activity.
GZK-111
HPLCmass spectrometry
cyclo-L-prolylglycine
neuroprotector
pharmacokinetics
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
28
05
2021
pubmed:
11
1
2022
medline:
1
4
2022
entrez:
10
1
2022
Statut:
ppublish
Résumé
We studied the pharmacokinetics of GZK-111 (N-phenylacetyl-glycyl-L-proline ethyl ether), a compound with neuroprotective activity, and its metabolite CPG (cyclo-L-prolylglycine) in rat blood plasma after single intravenous and intragastric administration in a dose of 20 mg/kg. It was found that the parent drug undergoes intensive biotransformation; its metabolite CPG persists in the circulation more than twice as long as GZK-111 and its plasma concentrations were higher by 50-70 times than the concentrations of the parent compound.
Identifiants
pubmed: 35006488
doi: 10.1007/s10517-022-05400-x
pii: 10.1007/s10517-022-05400-x
doi:
Substances chimiques
Dipeptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
310-313Informations de copyright
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.
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