Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug.

Drug Carriers / chemistry Ionic Liquids / chemistry Linoleic Acid Peptides Skin Absorption Surface-Active Agents / chemistry Water
ionic-liquid-in-oil nanodispersion leuprolide acetate lipid-based ionic liquids pharmacokinetics and biocompatibility stability transdermal peptide delivery

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
16 08 2021
Historique:
entrez: 10 1 2022
pubmed: 11 1 2022
medline: 9 4 2022
Statut: ppublish

Résumé

Lipid-based biocompatible ionic liquids (LBILs) have attracted attention as carriers in transdermal drug delivery systems (TDDSs) because of their lipophilic character. In this study, we report the formulation of a peptide-LBIL complex microencapsulated in an oil phase as a potential carrier for the transdermal delivery of leuprolide acetate as a model hydrophilic peptide. The peptide-LBIL complexes were prepared via a water-in-oil emulsion composed of 1,2-dimyristoyl-

Identifiants

DOI: 10.1021/acsabm.1c00563 PMID: 35006923
pubmed: 35006923
doi: 10.1021/acsabm.1c00563
doi:

Substances chimiques

Drug Carriers 0
Ionic Liquids 0
Peptides 0
Surface-Active Agents 0
Water 059QF0KO0R
Linoleic Acid 9KJL21T0QJ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6256-6267

Auteurs

Shihab Uddin (S)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Md Rafiqul Islam (MR)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
ORCID: 0000-0003-4056-1024

Md Raihan Chowdhury (MR)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0003-1085-1258

Rie Wakabayashi (R)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0003-0348-8091

Noriho Kamiya (N)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Division of Biotechnology, Centre for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0003-4898-6342

Muhammad Moniruzzaman (M)

Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia.
ORCID: 0000-0002-2523-4159

Masahiro Goto (M)

Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
Division of Biotechnology, Centre for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0002-2008-9351

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Liquides ioniques › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Acides linoléiques › Acide linoléique › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Phénomènes physiologiques du système tégumentaire › Phénomènes physiologiques de la peau › Absorption cutanée › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Tensioactifs › Lipid-Based Ionic-Liquid-Mediated...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Lipid-Based Ionic-Liquid-Mediated...