Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence.

Colonic Neoplasms / epidemiology Exercise Humans Neoplasm Recurrence, Local
Biological mechanism Colon cancer Exercise Inflammation Myokines Physical activity

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 30 08 2019
revised: 07 11 2021
accepted: 05 01 2022
pubmed: 11 1 2022
medline: 9 2 2022
entrez: 10 1 2022
Statut: ppublish

Résumé

Numerous epidemiological studies indicate that physical activity has a protective effect against colon cancer development and progression. Further, the relevant biological mechanisms where physical activity or exercise may improve survival have also been initially examined. In this review, we provide an overview of the epidemiological evidence to date which comprises 16 cohort studies of the effects of physical activity on colon cancer outcomes including cancer recurrence, cancer-specific and overall survival. Moreover, we present four potential mechanisms involving shear pressure, systemic milieu alteration, extracellular vesicles, and immune function by which physical activity and exercise may favorably impact colon cancer. Research currently in progress will provide definitive evidence of survival benefits resulting from exercise and future work will help clarify the role of targeted exercise and the relevant mechanisms involved.

Identifiants

DOI: 10.1016/j.critrevonc.2022.103578 PMID: 35007701
pubmed: 35007701
pii: S1040-8428(22)00002-6
doi: 10.1016/j.critrevonc.2022.103578
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103578

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Tianzhen Wang (T)

Department of Pathology, Harbin Medical University, Harbin, 150081, China; Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Ying Zhang (Y)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; Department of Physiology, Harbin Medical University, Harbin, 150081, China.

Dennis R Taaffe (DR)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Jin-Soo Kim (JS)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Hao Luo (H)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Lirui Yang (L)

School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Ciaran M Fairman (CM)

Exercise Science Department, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

Yuandong Qiao (Y)

Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, China.

Robert U Newton (RU)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.

Daniel A Galvão (DA)

Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. Electronic address: d.galvao@ecu.edu.au.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Protective effects of physical activity in...
questionsmedicales.fr › Activités humaines › Exercice physique › Protective effects of physical activity in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protective effects of physical activity in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Protective effects of physical activity in...