tRNA
internal tRFs
itRF
molecular diagnostics
non-coding RNAs (ncRNAs)
tRFs
tRNA fragments
tRNA-derived small fragments (tsRNAs)
transfer RNAs
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Dec 2021
22 Dec 2021
Historique:
received:
19
10
2021
revised:
15
12
2021
accepted:
16
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
Epithelial ovarian cancer (EOC) remains a highly-lethal gynecological malignancy, characterized by frequent recurrence, chemotherapy resistance and poor 5-year survival. Identifying novel predictive molecular markers remains an overdue challenge in the disease's clinical management. Herein, in silico analysis of TCGA-OV highlighted the tRNA-derived internal fragment (i-tRF-GlyGCC) among the most abundant tRFs in ovarian tumors, while target prediction and gene ontology (GO) enrichment analysis predicted its implication in key biological processes. Thereafter, i-tRF-GlyGCC levels were quantified in a screening EOC (
Identifiants
pubmed: 35008188
pii: cancers14010024
doi: 10.3390/cancers14010024
pmc: PMC8750938
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stavros Niarchos Foundation
ID : 16785
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