The Impact of Biomarkers in Pancreatic Ductal Adenocarcinoma on Diagnosis, Surveillance and Therapy.
biomarker
molecular diagnostics
pancreatic ductal adenocarcinoma
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Jan 2022
03 Jan 2022
Historique:
received:
30
11
2021
revised:
21
12
2021
accepted:
22
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is still difficult to treat due to insufficient methods for early diagnosis and prediction of therapy response. Furthermore, surveillance after curatively intended surgery lacks adequate methods for timely detection of recurrence. Therefore, several molecules have been analyzed as predictors of recurrence or early detection of PDAC. Enhanced understanding of molecular tumorigenesis and treatment response triggered the identification of novel biomarkers as predictors for response to conventional chemotherapy or targeted therapy. In conclusion, progress has been made especially in the prediction of therapy response with biomarkers. The use of molecules for early detection and recurrence of PDAC is still at an early stage, but there are promising approaches in noninvasive biomarkers, composite panels and scores that can already ameliorate the current clinical practice. The present review summarizes the current state of research on biomarkers for diagnosis and therapy of pancreatic cancer.
Identifiants
pubmed: 35008381
pii: cancers14010217
doi: 10.3390/cancers14010217
pmc: PMC8750069
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : PE 3337/1-1
Références
Ann Oncol. 2015 Sep;26 Suppl 5:v56-68
pubmed: 26314780
Am J Cancer Res. 2014 Nov 19;4(6):663-73
pubmed: 25520858
Curr Genomics. 2019 Dec;20(8):569-580
pubmed: 32581645
Cancers (Basel). 2019 Dec 18;12(1):
pubmed: 31861288
Mol Clin Oncol. 2014 Mar;2(2):265-268
pubmed: 24649344
J Natl Cancer Inst. 2015 May 29;107(8):
pubmed: 26025324
Genome Biol. 2017 May 5;18(1):83
pubmed: 28476144
Br J Cancer. 2016 Dec 6;115(12):1520-1529
pubmed: 27802454
Gastroenterology. 2009 Jan;136(1):187-95
pubmed: 18992248
Medicine (Baltimore). 2020 Jan;99(3):e18581
pubmed: 32011436
Ann Surg. 2019 Jun;269(6):1154-1162
pubmed: 31082915
Clin Cancer Res. 2006 Apr 15;12(8):2492-7
pubmed: 16638857
Pancreatology. 2017 Sep - Oct;17(5):738-753
pubmed: 28735806
Int J Cancer. 2021 Apr 15;148(8):2048-2058
pubmed: 33411965
Clin Chem. 2014 Oct;60(10):1282-9
pubmed: 25015375
Sci Transl Med. 2017 Jul 12;9(398):
pubmed: 28701476
Pancreatology. 2016 Nov - Dec;16(6):1057-1062
pubmed: 27692554
Nat Rev Clin Oncol. 2020 Feb;17(2):108-123
pubmed: 31705130
Br J Cancer. 2018 Apr;118(7):947-954
pubmed: 29515256
HPB (Oxford). 2018 Apr;20(4):297-304
pubmed: 29366815
Signal Transduct Target Ther. 2020 Aug 3;5(1):144
pubmed: 32747657
Int J Epidemiol. 2015 Feb;44(1):186-98
pubmed: 25502106
Curr Oncol. 2011 Jan;18(1):18-25
pubmed: 21331278
J Clin Med. 2021 Mar 19;10(6):
pubmed: 33808853
Drugs. 2020 May;80(7):647-669
pubmed: 32306207
Arch Intern Med. 2010 May 10;170(9):791-802
pubmed: 20458087
N Engl J Med. 2020 Sep 24;383(13):1207-1217
pubmed: 32955176
PLoS One. 2014 Apr 18;9(4):e94928
pubmed: 24747429
Transl Oncol. 2014 Aug;7(4):464-71
pubmed: 24956938
Am J Pathol. 2019 Jan;189(1):9-21
pubmed: 30558727
J Natl Compr Canc Netw. 2017 May;15(5):555-562
pubmed: 28476735
Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):363-369
pubmed: 30333217
J Clin Oncol. 2007 May 20;25(15):1960-6
pubmed: 17452677
Pancreas. 2015 Oct;44(7):1024-35
pubmed: 26335014
Cancers (Basel). 2016 Apr 18;8(4):
pubmed: 27096871
Gut. 2018 Jan;67(1):128-137
pubmed: 28108468
Pancreas. 1994 Nov;9(6):703-6
pubmed: 7846012
N Engl J Med. 2011 May 12;364(19):1817-25
pubmed: 21561347
Br J Cancer. 2009 Oct 6;101(7):1162-7
pubmed: 19724276
Hepatogastroenterology. 2000 Nov-Dec;47(36):1750-2
pubmed: 11149048
J Natl Cancer Inst. 2014 Jan;106(1):djt347
pubmed: 24301456
Mol Oncol. 2016 Mar;10(3):481-93
pubmed: 26856794
Ann Oncol. 2014 May;25(5):1025-32
pubmed: 24562449
Oncol Res Treat. 2018;41(10):603-610
pubmed: 30269131
Gastroenterology. 2016 Aug;151(2):267-70
pubmed: 27343369
Dis Markers. 2010;28(4):241-51
pubmed: 20534909
Genes (Basel). 2019 Dec 23;11(1):
pubmed: 31877923
Cancers (Basel). 2020 May 31;12(6):
pubmed: 32486461
Nature. 2016 Mar 3;531(7592):47-52
pubmed: 26909576
Int J Cancer. 2021 Mar 15;148(6):1508-1518
pubmed: 33128797
Ann Oncol. 2012 Jul;23(7):1713-22
pubmed: 22241899
J Clin Oncol. 2018 Jun 1;36(16):1631-1641
pubmed: 29504847
Cancer Biol Ther. 2009 Feb;8(4):340-6
pubmed: 19106647
Pancreas. 2016 May-Jun;45(5):761-71
pubmed: 26784908
Nucl Med Commun. 2020 May;41(5):411-415
pubmed: 32168264
Gut. 2021 Mar;70(3):606-617
pubmed: 32855305
J Biol Regul Homeost Agents. 2017 Apr-Jun;31(2):383-388
pubmed: 28685541
Pancreatology. 2010;10(1):66-73
pubmed: 20332664
J Immunother. 2010 Feb-Mar;33(2):219-24
pubmed: 20139773
EMBO Mol Med. 2012 Mar;4(3):143-59
pubmed: 22351564
Cancer Genet. 2013 Jun;206(6):217-21
pubmed: 23933230
Gastroenterology. 2019 May;156(6):1742-1752
pubmed: 30677401
N Engl J Med. 2018 Feb 22;378(8):731-739
pubmed: 29466156
Gastroenterology. 2021 Feb;160(3):744-754
pubmed: 33058868
Ann Surg. 2018 May;267(5):936-945
pubmed: 28338509
Tumour Biol. 2017 Jun;39(6):1010428317692231
pubmed: 28618958
PLoS One. 2015 Jun 29;10(6):e0130996
pubmed: 26121640
Pancreas. 2013 Nov;42(8):1303-10
pubmed: 24152955
Int J Cancer. 2021 Dec 15;149(12):2063-2074
pubmed: 34319586
J Pharmacol Sci. 2015 Mar;127(3):319-25
pubmed: 25837929
World J Gastroenterol. 2016 Oct 14;22(38):8480-8488
pubmed: 27784960
Front Genet. 2020 Dec 02;11:596078
pubmed: 33424927
JCO Precis Oncol. 2018;2018:
pubmed: 30637364
Pancreatology. 2017 Mar - Apr;17(2):255-262
pubmed: 28189431
Cancer Res. 2006 Apr 1;66(7):3928-35
pubmed: 16585222
Gastroenterology. 2017 Jan;152(1):68-74.e2
pubmed: 27856273
Case Rep Oncol. 2020 Oct 13;13(3):1239-1243
pubmed: 33250737
Drug Metab Dispos. 2011 Jan;39(1):132-9
pubmed: 20930123
J Natl Cancer Inst. 2017 Aug 1;109(8):
pubmed: 28376184
N Engl J Med. 2019 Jul 25;381(4):317-327
pubmed: 31157963
Clin Cancer Res. 2020 Sep 1;26(17):4661-4669
pubmed: 32532788
Comput Struct Biotechnol J. 2020 Nov 21;18:3606-3614
pubmed: 33304458
Cancer Causes Control. 2010 Jul;21(7):1047-59
pubmed: 20349126
Ann Oncol. 2018 Jan 1;29(1):223-229
pubmed: 29045505
Nat Rev Gastroenterol Hepatol. 2011 Mar;8(3):141-50
pubmed: 21383670
Mol Cancer Ther. 2016 Apr;15(4):680-8
pubmed: 26832793
Br J Cancer. 2020 Feb;122(3):333-339
pubmed: 31787751
J Hum Genet. 2017 Jan;62(1):33-40
pubmed: 27251005
Gastroenterol Res Pract. 2018 Nov 21;2018:8704751
pubmed: 30584422
Biomarkers. 2020 Mar;25(2):186-193
pubmed: 32009482
Clin Cancer Res. 2015 Nov 1;21(21):4811-8
pubmed: 26169969
Int J Clin Exp Med. 2015 Jul 15;8(7):11683-91
pubmed: 26380005
Clin Cancer Res. 2011 Jan 15;17(2):302-9
pubmed: 21098698
Mol Oncol. 2019 Feb;13(2):212-227
pubmed: 30358104
Oncogene. 2014 Jul 17;33(29):3812-9
pubmed: 23995783
Pancreatology. 2018 Dec;18(8):971-976
pubmed: 30131287
Lancet. 2011 Aug 13;378(9791):607-20
pubmed: 21620466
Diagnostics (Basel). 2021 Mar 20;11(3):
pubmed: 33804776
PLoS One. 2019 Aug 15;14(8):e0221169
pubmed: 31415645
Int J Cancer. 2007 Mar 15;120(6):1355-63
pubmed: 17131328
Nature. 2015 Jul 9;523(7559):177-82
pubmed: 26106858
Theranostics. 2019 Feb 12;9(5):1280-1287
pubmed: 30867830
Front Oncol. 2020 Sep 17;10:1466
pubmed: 33042793
Am J Cancer Res. 2015 Oct 15;5(11):3455-66
pubmed: 26807325
Adv Enzyme Regul. 2001;41:151-7
pubmed: 11384742
Clin Cancer Res. 2004 Oct 15;10(20):6956-61
pubmed: 15501974
World J Gastroenterol. 2004 Jun 1;10(11):1675-7
pubmed: 15162550
Cancer Discov. 2018 Sep;8(9):1087-1095
pubmed: 29802158
Clin Cancer Res. 2005 Sep 1;11(17):6100-2
pubmed: 16144907
Prog Mol Biol Transl Sci. 2019;162:229-239
pubmed: 30905452
Cancer Res. 2021 Apr 1;81(7):1654-1666
pubmed: 33648930
Ann Surg Oncol. 2018 Nov;25(12):3483-3491
pubmed: 29786131
Gut. 2018 Dec;67(12):2142-2155
pubmed: 29080858
Front Oncol. 2019 Aug 27;9:773
pubmed: 31552163
JAMA. 2014 Jan 22-29;311(4):392-404
pubmed: 24449318
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Hematol Oncol. 2020 Oct 2;13(1):130
pubmed: 33008426
Oncol Res Treat. 2020;43(11):628-636
pubmed: 33099551
Exp Cell Res. 2019 Oct 1;383(1):111543
pubmed: 31374207
Clin Cancer Res. 2019 Dec 1;25(23):7014-7023
pubmed: 31540979
Cancers (Basel). 2020 Dec 03;12(12):
pubmed: 33287390
Eur J Surg Oncol. 2019 Oct;45(10):1770-1777
pubmed: 31204168
Nat Commun. 2020 Oct 19;11(1):5270
pubmed: 33077732
BMC Genomics. 2015;16 Suppl 9:S4
pubmed: 26328610
Oncol Rep. 2007 May;17(5):1201-5
pubmed: 17390066
N Engl J Med. 2013 Oct 31;369(18):1691-703
pubmed: 24131140
J Natl Cancer Inst. 2013 Jul 17;105(14):1027-35
pubmed: 23847240
Nat Commun. 2015 Jul 07;6:7686
pubmed: 26154128
Science. 2017 Jul 28;357(6349):409-413
pubmed: 28596308
Nat Cell Biol. 2021 Jun;23(6):631-641
pubmed: 34108659
Gastroenterology. 2021 Mar;160(4):1373-1383.e6
pubmed: 33333055
Pancreatology. 2019 Mar;19(2):302-306
pubmed: 30737189
Eur J Surg Oncol. 2007 Apr;33(3):266-70
pubmed: 17097848
World J Gastroenterol. 2014 Nov 14;20(42):15682-90
pubmed: 25400452
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):394-403
pubmed: 28801248
Indian J Surg Oncol. 2011 Jun;2(2):88-100
pubmed: 22693400