Advances and Challenges of Antibody Therapeutics for Severe Bronchial Asthma.
antibody therapeutics
asthma
biomarker
refractory asthma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Dec 2021
22 Dec 2021
Historique:
received:
07
09
2021
revised:
17
12
2021
accepted:
20
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
1
2
2022
Statut:
epublish
Résumé
Asthma is a disease that consists of three main components: airway inflammation, airway hyperresponsiveness, and airway remodeling. Persistent airway inflammation leads to the destruction and degeneration of normal airway tissues, resulting in thickening of the airway wall, decreased reversibility, and increased airway hyperresponsiveness. The progression of irreversible airway narrowing and the associated increase in airway hyperresponsiveness are major factors in severe asthma. This has led to the identification of effective pharmacological targets and the recognition of several biomarkers that enable a more personalized approach to asthma. However, the efficacies of current antibody therapeutics and biomarkers are still unsatisfactory in clinical practice. The establishment of an ideal phenotype classification that will predict the response of antibody treatment is urgently needed. Here, we review recent advancements in antibody therapeutics and novel findings related to the disease process for severe asthma.
Identifiants
pubmed: 35008504
pii: ijms23010083
doi: 10.3390/ijms23010083
pmc: PMC8744863
pii:
doi:
Substances chimiques
Antibodies
0
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP20fk0108129
Organisme : Japan Agency for Medical Research and Development
ID : JP21lm0203007
Organisme : GlaxoSmithKline (United States)
ID : A-32
Organisme : Japan Society for the Promotion of Science
ID : JP21K16118
Organisme : the Japan Intractable Diseases (Nanbyo) Research Foundation
ID : 2020B02
Références
J Appl Physiol (1985). 2013 Apr;114(7):834-43
pubmed: 23305987
Allergy Asthma Immunol Res. 2016 Nov;8(6):491-8
pubmed: 27582399
Respir Med. 2017 Sep;130:55-60
pubmed: 29206634
Front Pharmacol. 2021 Apr 19;12:630334
pubmed: 33953671
Nat Immunol. 2008 Jan;9(1):25-33
pubmed: 18066066
Eur Respir J. 2021 Dec 31;59(1):
pubmed: 34049943
Nat Immunol. 2002 Jul;3(7):673-80
pubmed: 12055625
J Allergy Clin Immunol Pract. 2021 Mar;9(3):1194-1200
pubmed: 33069885
Eur Respir J. 2007 Mar;29(3):596-604
pubmed: 17329494
J Mol Biol. 2017 Jan 20;429(2):208-219
pubmed: 27956146
Thorax. 2018 Aug;73(8):782-784
pubmed: 29079610
Allergol Int. 2014 Sep;63(3):487-8
pubmed: 24851946
Chest. 2020 Aug;158(2):491-500
pubmed: 32275980
Int J Clin Pharmacol Ther. 2011 Dec;49(12):713-21
pubmed: 22122813
J Allergy Clin Immunol. 2020 Mar;145(3):808-817.e2
pubmed: 31805312
N Engl J Med. 2017 Jun 22;376(25):2448-2458
pubmed: 28530840
J Asthma Allergy. 2014 Sep 04;7:123-30
pubmed: 25214796
Ann Intern Med. 2011 May 3;154(9):573-82
pubmed: 21536936
Lancet Respir Med. 2021 Jan;9(1):43-56
pubmed: 32979986
N Engl J Med. 2014 May 29;370(22):2102-10
pubmed: 24846652
Allergy. 2007 Feb;62(2):154-61
pubmed: 17298424
Lancet Respir Med. 2017 May;5(5):390-400
pubmed: 28395936
N Engl J Med. 2018 Jun 28;378(26):2486-2496
pubmed: 29782217
Expert Opin Investig Drugs. 2019 Nov;28(11):931-940
pubmed: 31549891
Am J Respir Cell Mol Biol. 2011 Feb;44(2):127-33
pubmed: 20525803
Exp Lung Res. 2018 Aug;44(6):288-301
pubmed: 30428724
Eur Respir J. 2018 Oct 18;52(4):
pubmed: 30139780
J Clin Invest. 2004 Feb;113(4):551-60
pubmed: 14966564
Lancet. 2020 Feb 1;395(10221):371-383
pubmed: 32007172
Expert Opin Emerg Drugs. 2016 Dec;21(4):359-364
pubmed: 27690668
Clin Exp Allergy. 2020 Jan;50(1):5-14
pubmed: 31505066
Chest. 2021 Feb;159(2):496-506
pubmed: 32882249
J Allergy Clin Immunol. 2016 May;137(5):1317-24
pubmed: 27155028
Biomed Res Int. 2018 May 10;2018:4839230
pubmed: 29862274
Biochem Biophys Res Commun. 2018 Sep 26;504(1):19-24
pubmed: 30126632
J Asthma Allergy. 2021 May 27;14:575-583
pubmed: 34079295
Respir Med. 2009 Nov;103(11):1633-42
pubmed: 19619998
N Engl J Med. 2017 Sep 7;377(10):965-976
pubmed: 28877019
Pulm Pharmacol Ther. 2017 Jun;44:38-45
pubmed: 28302544
Lancet. 2000 Dec 23-30;356(9248):2144-8
pubmed: 11191542
Int Arch Allergy Immunol. 2006;139(2):122-31
pubmed: 16374021
Br J Pharmacol. 2020 Oct;177(20):4750-4765
pubmed: 32857420
N Engl J Med. 2014 Sep 25;371(13):1198-207
pubmed: 25199059
Front Physiol. 2017 Dec 12;8:1012
pubmed: 29311954
J Thorac Dis. 2020 Dec;12(12):7097-7105
pubmed: 33447398
Int Immunol. 2021 Nov 25;33(12):659-663
pubmed: 34165514
J Exp Med. 2007 Feb 19;204(2):253-8
pubmed: 17242164
Lancet Respir Med. 2016 Oct;4(10):781-796
pubmed: 27616196
J Allergy Clin Immunol. 2013 Dec;132(6):1295-302
pubmed: 23998657
Cochrane Database Syst Rev. 2017 Sep 21;9:CD010834
pubmed: 28933516
N Engl J Med. 2021 May 13;384(19):1800-1809
pubmed: 33979488
Chest. 2016 Oct;150(4):799-810
pubmed: 27018175
Blood Adv. 2017 Mar 30;1(10):577-589
pubmed: 29296700
J Allergy Clin Immunol. 2014 Feb;133(2):388-94
pubmed: 24075231
J Allergy Clin Immunol. 2011 Feb;127(2):382-389.e1-13
pubmed: 21195471
J Allergy Clin Immunol Pract. 2020 Feb;8(2):516-526
pubmed: 31521831
Eur Respir J. 2021 Oct 7;58(4):
pubmed: 34326187
Eur Respir J. 2020 Nov 12;56(5):
pubmed: 32586879
Am J Respir Crit Care Med. 2013 Apr 15;187(8):804-11
pubmed: 23471469
Lancet Respir Med. 2015 May;3(5):355-66
pubmed: 25736990
AJR Am J Roentgenol. 2002 Nov;179(5):1245-52
pubmed: 12388508
Allergy. 2005 Mar;60(3):309-16
pubmed: 15679715
Immunity. 2020 Mar 17;52(3):542-556.e13
pubmed: 32187520
Eur Respir J. 2014 Feb;43(2):343-73
pubmed: 24337046
J Asthma. 2021 Jul 1;:1-9
pubmed: 34121592
J Asthma Allergy. 2019 Nov 19;12:375-387
pubmed: 31819539
Br J Clin Pharmacol. 2018 Feb;84(2):339-348
pubmed: 29044640
Lancet Respir Med. 2015 Sep;3(9):692-701
pubmed: 26231288
Nat Immunol. 2015 Jan;16(1):27-35
pubmed: 25521682
Lancet Respir Med. 2018 Jul;6(7):511-525
pubmed: 29792288
J Clin Invest. 2008 Nov;118(11):3546-56
pubmed: 18982161
J Allergy Clin Immunol. 2016 Nov;138(5):1301-1308.e2
pubmed: 27113848
Drug Des Devel Ther. 2018 Mar 21;12:619-628
pubmed: 29606855
Immun Inflamm Dis. 2018 Sep;6(3):382-391
pubmed: 29737044
J Allergy Clin Immunol. 2013 Oct;132(4):933-41
pubmed: 23810766
J Asthma Allergy. 2015 Aug 10;8:87-92
pubmed: 26309415
J Allergy Clin Immunol. 2015 Oct;136(4):904-13
pubmed: 25936567
Respir Res. 2021 Jun 22;22(1):184
pubmed: 34158028
Lancet. 2016 Oct 29;388(10056):2115-2127
pubmed: 27609408
Expert Rev Clin Immunol. 2017 May;13(5):425-437
pubmed: 28277826
PLoS One. 2013;8(1):e51268
pubmed: 23300949
Lancet Respir Med. 2015 Nov;3(11):849-58
pubmed: 26493938
Ann Allergy Asthma Immunol. 2021 Jul;127(1):147-149
pubmed: 33848633
Eur Respir J. 2019 Jan 31;53(2):
pubmed: 30442714
PLoS One. 2013;8(2):e56015
pubmed: 23457493
Pulm Pharmacol Ther. 2020 Apr;61:101899
pubmed: 31972327
N Engl J Med. 2009 Mar 5;360(10):973-84
pubmed: 19264686
Allergy. 2015 May;70(5):556-67
pubmed: 25683166
J Allergy Clin Immunol. 2017 Jul;140(1):162-169.e2
pubmed: 27826098
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Expert Opin Biol Ther. 2017 Dec;17(12):1565-1572
pubmed: 28990423
Proc Am Thorac Soc. 2009 May 1;6(3):301-5
pubmed: 19387034
Chest. 2021 May;159(5):1734-1746
pubmed: 33333058
Adv Immunol. 2007;93:63-119
pubmed: 17383539
Lancet. 2016 Oct 29;388(10056):2128-2141
pubmed: 27609406
Clin Exp Allergy. 2016 Dec;46(12):1614-1616
pubmed: 27770456
N Engl J Med. 2017 Sep 7;377(10):936-946
pubmed: 28877011
Eur Respir J. 2019 Nov 14;54(5):
pubmed: 31391226
Intern Med. 2020 Nov 15;59(22):2849-2855
pubmed: 32713920
Clin Exp Allergy. 2005 Sep;35(9):1175-9
pubmed: 16164444
J Clin Invest. 2015 May;125(5):2021-31
pubmed: 25866971
Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24
pubmed: 19815809
Pharmacol Res. 2020 May;155:104490
pubmed: 31682916
Thorax. 2015 Feb;70(2):115-20
pubmed: 25422384
PLoS One. 2015 Sep 08;10(9):e0136284
pubmed: 26348727
JAMA. 2016 Feb 2;315(5):469-79
pubmed: 26836729
Drug Des Devel Ther. 2017 Oct 30;11:3137-3144
pubmed: 29133975
J Pers Med. 2021 Jan 28;11(2):
pubmed: 33525548
Allergol Int. 2017 Apr;66(2):163-189
pubmed: 28196638
Immunity. 2005 Nov;23(5):479-90
pubmed: 16286016
Chest. 2016 Oct;150(4):789-798
pubmed: 27056586
BMC Pulm Med. 2019 Jan 7;19(1):5
pubmed: 30616547
Cochrane Database Syst Rev. 2014 Jan 13;(1):CD003559
pubmed: 24414989
J Allergy Clin Immunol. 2018 Oct;142(4):1185-1193.e4
pubmed: 29890236