Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.
HPV
genomic landscape
molecular analysis
next generation sequencing
penile cancer
penile squamous cell carcinoma
whole-exome sequencing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Dec 2021
27 Dec 2021
Historique:
received:
30
11
2021
revised:
22
12
2021
accepted:
23
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
2
2
2022
Statut:
epublish
Résumé
Penile squamous cell carcinoma (PSCC) is a rare but aggressive neoplasm with dual pathogenesis (human papillomavirus (HPV)-associated and HPV-independent). The development of targeted treatment is hindered by poor knowledge of the molecular landscape of PSCC. We performed a thorough review of genetic alterations of PSCC focused on somatic mutations and/or copy number alterations. A total of seven articles have been identified which, overall, include 268 PSCC. However, the series are heterogeneous regarding methodologies employed for DNA sequencing and HPV detection together with HPV prevalence, and include, in general, a limited number of cases, which results in markedly different findings. Reported top-ranked mutations involve
Identifiants
pubmed: 35008677
pii: ijms23010251
doi: 10.3390/ijms23010251
pmc: PMC8745288
pii:
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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