Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes.
biomarkers
epigenomics
genomics
nucleic acid
transcriptomics
type 2 diabetes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Dec 2021
28 Dec 2021
Historique:
received:
10
12
2021
revised:
25
12
2021
accepted:
26
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
2
2
2022
Statut:
epublish
Résumé
Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D will result in chronic high blood sugar levels, eventually resulting in T2D complications. These complications, such as kidney, eye, and nerve damage, are even harder to treat. Identifying individuals at high risk of developing T2D and its complications is essential for early prevention and treatment. Numerous studies have been done to identify biomarkers for T2D diagnosis and prognosis. This review focuses on recent T2D biomarker studies based on circulating nucleic acids using different omics technologies: genomics, transcriptomics, and epigenomics. Omics studies have profiled biomarker candidates from blood, urine, and other non-invasive samples. Despite methodological differences, several candidate biomarkers were reported for the risk and diagnosis of T2D, the prognosis of T2D complications, and pharmacodynamics of T2D treatments. Future studies should be done to validate the findings in larger samples and blood-based biomarkers in non-invasive samples to support the realization of precision medicine for T2D.
Identifiants
pubmed: 35008723
pii: ijms23010295
doi: 10.3390/ijms23010295
pmc: PMC8745431
pii:
doi:
Substances chimiques
Biomarkers
0
Cell-Free Nucleic Acids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union
ID : 754432
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