High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling.
Adult
Biopsy
Cell Proliferation
Cohort Studies
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Ontology
Humans
Middle Aged
Neoplasm Grading
Neoplasm Proteins
/ metabolism
Papillomavirus Infections
/ immunology
Signal Transduction
/ genetics
Uterine Cervical Neoplasms
/ genetics
Uterine Cervical Dysplasia
/ genetics
CIN progression
cervical cancer screening
differential gene expression
transcriptomic analysis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Dec 2021
29 Dec 2021
Historique:
received:
01
12
2021
accepted:
27
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
10
2
2022
Statut:
epublish
Résumé
Implementation of high-risk human papilloma virus (HPV) screening and the increasing proportion of HPV vaccinated women in the screening program will reduce the percentage of HPV positive women with oncogenic potential. In search of more specific markers to identify women with high risk of cancer development, we used RNA sequencing to compare the transcriptomic immune-profile of 13 lesions with cervical intraepithelial neoplasia grade 3 (CIN3) or adenocarcinoma in situ (AIS) and 14 normal biopsies from women with detected HPV infections. In CIN3/AIS lesions as compared to normal tissue, 27 differential expressed genes were identified. Transcriptomic analysis revealed significantly higher expression of a number of genes related to proliferation, (
Identifiants
pubmed: 35008799
pii: ijms23010373
doi: 10.3390/ijms23010373
pmc: PMC8745058
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Folke Hermansen Fond
ID : year (2014-20219
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