The Role of Molecular Imaging as a Marker of Remyelination and Repair in Multiple Sclerosis.
disease progression
magnetic resonance spectroscopy (MRS)
molecular biomarkers
multiple sclerosis
neurodegeneration
neuroprotection
positron emission tomography (PET)
remyelination
sodium imaging
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Dec 2021
31 Dec 2021
Historique:
received:
30
11
2021
revised:
26
12
2021
accepted:
29
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
2
2022
Statut:
epublish
Résumé
The appearance of new disease-modifying therapies in multiple sclerosis (MS) has revolutionized our ability to fight inflammatory relapses and has immensely improved patients' quality of life. Although remarkable, this achievement has not carried over into reducing long-term disability. In MS, clinical disability progression can continue relentlessly irrespective of acute inflammation. This "silent" disease progression is the main contributor to long-term clinical disability in MS and results from chronic inflammation, neurodegeneration, and repair failure. Investigating silent disease progression and its underlying mechanisms is a challenge. Standard MRI excels in depicting acute inflammation but lacks the pathophysiological lens required for a more targeted exploration of molecular-based processes. Novel modalities that utilize nuclear magnetic resonance's ability to display in vivo information on imaging look to bridge this gap. Displaying the CNS through a molecular prism is becoming an undeniable reality. This review will focus on "molecular imaging biomarkers" of disease progression, modalities that can harmoniously depict anatomy and pathophysiology, making them attractive candidates to become the first valid biomarkers of neuroprotection and remyelination.
Identifiants
pubmed: 35008899
pii: ijms23010474
doi: 10.3390/ijms23010474
pmc: PMC8745199
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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