Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.
Aminohydrolases
/ genetics
Animals
Choline
/ analysis
Choline Deficiency
/ genetics
Developmental Disabilities
/ epidemiology
Disease Models, Animal
Embryonic Development
/ genetics
Female
Folic Acid
/ metabolism
Formate-Tetrahydrofolate Ligase
/ deficiency
Genotype
Incidence
Liver
/ metabolism
Maternal Nutritional Physiological Phenomena
/ genetics
Methenyltetrahydrofolate Cyclohydrolase
/ deficiency
Methylenetetrahydrofolate Dehydrogenase (NADP)
/ deficiency
Mice
Multienzyme Complexes
/ genetics
Multifunctional Enzymes
/ deficiency
Polymorphism, Single Nucleotide
Pregnancy
MTHFD1
birth defects
choline
developmental defects
developmental delay
embryonic development
folate
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Dec 2021
28 Dec 2021
Historique:
received:
16
11
2021
revised:
23
12
2021
accepted:
24
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
20
1
2022
Statut:
epublish
Résumé
Folate and choline are interconnected metabolically. The MTHFD1 R653Q SNP is a risk factor for birth defects and there are concerns that choline deficiency may interact with this SNP and exacerbate health risks. 80-90% of women do not meet the Adequate Intake (AI) for choline. The objective of this study was to assess the effects of choline deficiency on maternal one-carbon metabolism and reproductive outcomes in the MTHFD1-synthetase deficient mouse (
Identifiants
pubmed: 35011003
pii: nu14010127
doi: 10.3390/nu14010127
pmc: PMC8747146
pii:
doi:
Substances chimiques
Mthfd1 protein, mouse
0
Multienzyme Complexes
0
Multifunctional Enzymes
0
formyl-methenyl-methylenetetrahydrofolate synthetase
73699-18-0
Folic Acid
935E97BOY8
Methylenetetrahydrofolate Dehydrogenase (NADP)
EC 1.5.1.5
Aminohydrolases
EC 3.5.4.-
Methenyltetrahydrofolate Cyclohydrolase
EC 3.5.4.9
Formate-Tetrahydrofolate Ligase
EC 6.3.4.3
Choline
N91BDP6H0X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-156389
Pays : Canada
Organisme : Natural Sciences and Engineering Research Council
ID : RES 25104
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