Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands.
amino acid homeostasis
intracellular kinetics
l-type amino acid transporter 1 (LAT1)
targeted drug delivery
transporter regulation
transporter study methodology
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Dec 2021
22 Dec 2021
Historique:
received:
05
11
2021
revised:
20
12
2021
accepted:
21
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
11
2
2022
Statut:
epublish
Résumé
l-Type amino acid transporter 1 (LAT1), expressed abundantly in the brain and placenta and overexpressed in several cancer cell types, has gained a lot of interest in drug research and development, as it can be utilized for brain-targeted drug delivery, as well as inhibiting the essential amino acid supply to cancer cells. The structure of LAT1 is today very well-known and the interactions of ligands at the binding site of LAT1 can be modeled and explained. However, less is known of LAT1's life cycle within the cells. Moreover, the functionality of LAT1 can be measured by several different methods, which may vary between the laboratories and make the comparison of the results challenging. In the present study, the usefulness of indirect
Identifiants
pubmed: 35011270
pii: molecules27010037
doi: 10.3390/molecules27010037
pmc: PMC8746705
pii:
doi:
Substances chimiques
Large Neutral Amino Acid-Transporter 1
0
Ligands
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Academy of Finland
ID : 294227, 294229, 307057, 311939
Organisme : Sigrid Jusélius Foundation
ID : 2015-2021
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