Bmp Signal Gradient Modulates Convergent Cell Movement via
Animals
Bone Morphogenetic Proteins
/ metabolism
Cell Movement
/ genetics
Cell Polarity
/ genetics
Embryo, Nonmammalian
/ cytology
Gastrulation
/ genetics
Gene Knockdown Techniques
Models, Biological
Protein Binding
/ genetics
Signal Transduction
Transcription, Genetic
Wnt Signaling Pathway
/ genetics
Xenopus Proteins
/ chemistry
Xenopus laevis
/ embryology
rhoA GTP-Binding Protein
/ metabolism
Bmp
Disheveled
Wnt-PCP
Xarhgef3.2
Xenopus
convergent extension
daam1
gastrulation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 12 2021
24 12 2021
Historique:
received:
18
10
2021
revised:
20
12
2021
accepted:
21
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Gastrulation is a critical step in the establishment of a basic body plan during development. Convergence and extension (CE) cell movements organize germ layers during gastrulation. Noncanonical Wnt signaling has been known as major signaling that regulates CE cell movement by activating Rho and Rac. In addition, Bmp molecules are expressed in the ventral side of a developing embryo, and the ventral mesoderm region undergoes minimal CE cell movement while the dorsal mesoderm undergoes dynamic cell movements. This suggests that Bmp signal gradient may affect CE cell movement. To investigate whether Bmp signaling negatively regulates CE cell movements, we performed microarray-based screening and found that the transcription of
Identifiants
pubmed: 35011606
pii: cells11010044
doi: 10.3390/cells11010044
pmc: PMC8750265
pii:
doi:
Substances chimiques
Bone Morphogenetic Proteins
0
Xenopus Proteins
0
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea (NRF)
ID : (2016R1D1A1B02008770, 2018M3C7A1056285, 2021R1A4A1027355, and 2021M3H9A1097557).
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