Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
Aged
Aged, 80 and over
Animals
Antigens, Fungal
/ immunology
Bone Marrow Cells
/ immunology
Dendritic Cells
/ immunology
Gene Expression Profiling
Gene Expression Regulation
Granulocyte Colony-Stimulating Factor
/ metabolism
Humans
Inflammation
/ pathology
Lectins, C-Type
/ genetics
Macrophage-1 Antigen
/ metabolism
Mice, Inbred C57BL
Middle Aged
Neutrophils
/ immunology
RNA, Messenger
/ genetics
Zymosan
/ metabolism
bone marrow
dectin-1
dendritic cells
fungal infection
granulopoiesis
hematopoiesis
zymosan
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 12 2021
24 12 2021
Historique:
received:
27
08
2021
revised:
15
12
2021
accepted:
16
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
26
2
2022
Statut:
epublish
Résumé
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are localized around sinusoids, can (cross)-present antigens, become activated upon intravenous LPS-injection, and for the most part belong to the cDC2 subtype which is associated with Th2/Th17 immunity. Gene-expression profiling revealed that BM-resident DCs are enriched for several c-type lectins, including Dectin-1, which can bind beta-glucans expressed on fungi and yeast. Indeed, DCs in BM were much more efficient in phagocytosis of both yeast-derived zymosan-particles and
Identifiants
pubmed: 35011617
pii: cells11010055
doi: 10.3390/cells11010055
pmc: PMC8750392
pii:
doi:
Substances chimiques
Antigens, Fungal
0
Lectins, C-Type
0
Macrophage-1 Antigen
0
RNA, Messenger
0
dectin 1
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Zymosan
9010-72-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131842
Pays : United States
Organisme : Sanquin Research grant
ID : PPOC13-030P
Organisme : Landsteiner Foundation for Blood Transfusion Research
ID : #1014
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