Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues.
Idefix
ZAM
gypsy
longevity
transposons
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
28 12 2021
28 12 2021
Historique:
received:
03
11
2021
revised:
22
12
2021
accepted:
26
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
3
3
2022
Statut:
epublish
Résumé
The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the
Identifiants
pubmed: 35011640
pii: cells11010079
doi: 10.3390/cells11010079
pmc: PMC8750722
pii:
doi:
Substances chimiques
Retroelements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : EU E-RARE 2017
ID : TREAT-HGPS
Organisme : AIProSaB
ID : 3/2019
Organisme : University of Bologna
ID : RFO2019
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