Insights into Modern Therapeutic Approaches in Pediatric Acute Leukemias.
CAR-T
PRR
antibodies
immune checkpoint inhibitors
immunotherapy
pediatric leukemias
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 01 2022
02 01 2022
Historique:
received:
14
10
2021
revised:
07
12
2021
accepted:
15
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Pediatric cancers predominantly constitute lymphomas and leukemias. Recently, our knowledge and awareness about genetic diversities, and their consequences in these diseases, have greatly expanded. Modern solutions are focused on mobilizing and impacting a patient's immune system. Strategies to stimulate the immune system, to prime an antitumor response, are of intense interest. Amid those types of therapies are chimeric antigen receptor T (CAR-T) cells, bispecific antibodies, and antibody-drug conjugates (ADC), which have already been approved in the treatment of acute lymphoblastic leukemia (ALL)/acute myeloid leukemia (AML). In addition, immune checkpoint inhibitors (ICIs), the pattern recognition receptors (PRRs), i.e., NOD-like receptors (NLRs), Toll-like receptors (TLRs), and several kinds of therapy antibodies are well on their way to showing significant benefits for patients with these diseases. This review summarizes the current knowledge of modern methods used in selected pediatric malignancies and presents therapies that may hold promise for the future.
Identifiants
pubmed: 35011701
pii: cells11010139
doi: 10.3390/cells11010139
pmc: PMC8749975
pii:
doi:
Substances chimiques
Antibodies, Bispecific
0
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Semin Hematol. 2010 Apr;47(2):156-69
pubmed: 20350663
Cancer Discov. 2015 Dec;5(12):1282-95
pubmed: 26516065
Molecules. 2020 Oct 16;25(20):
pubmed: 33081383
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Blood. 2005 May 1;105(9):3641-7
pubmed: 15650062
Mol Ther Nucleic Acids. 2013 Aug 13;2:e115
pubmed: 23941867
Clin Transl Immunology. 2020 Mar 03;9(3):e1117
pubmed: 32153780
J Clin Oncol. 2014 Sep 20;32(27):3021-32
pubmed: 25092781
Blood. 2011 Apr 28;117(17):4403-4
pubmed: 21527536
Trends Cancer. 2017 Sep;3(9):631-642
pubmed: 28867167
Int J Oncol. 2016 Aug;49(2):675-81
pubmed: 27277333
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3793-8
pubmed: 24567377
Leuk Res. 2020 Aug;95:106385
pubmed: 32521310
Int Immunopharmacol. 2021 Jan;90:107202
pubmed: 33278749
Br J Dermatol. 2020 May;182(5):1111-1119
pubmed: 31487383
Sci Transl Med. 2014 Feb 19;6(224):224ra25
pubmed: 24553386
Blood. 2013 Jun 13;121(24):4854-60
pubmed: 23591789
Leukemia. 2013 Sep;27(9):1832-40
pubmed: 23765228
J Leukoc Biol. 2017 Dec;102(6):1347-1356
pubmed: 29018147
Blood. 2002 Jul 1;100(1):29-35
pubmed: 12070004
Biol Blood Marrow Transplant. 2008 Nov;14(11):1245-52
pubmed: 18940679
Mol Ther. 2013 Nov;21(11):2122-9
pubmed: 23831595
Immunology. 2010 May;130(1):55-63
pubmed: 20002790
Br J Haematol. 2020 Jul;190(1):e53-e56
pubmed: 32424837
J Clin Med. 2015 Jan 09;4(1):127-49
pubmed: 26237023
Lancet. 2016 May 7;387(10031):1909-20
pubmed: 26952546
J Clin Oncol. 2016 Sep 10;34(26):3119-25
pubmed: 27269937
Front Immunol. 2016 Sep 28;7:390
pubmed: 27733853
Neurol Neuroimmunol Neuroinflamm. 2019 Dec 11;7(2):
pubmed: 31826986
J Pediatr Hematol Oncol. 2012 Mar;34(2):96-100
pubmed: 22146532
Blood. 2004 Oct 1;104(7):2124-33
pubmed: 15191948
Blood. 2018 Jul 26;132(4):405-412
pubmed: 29789356
J Immunol. 1998 Nov 1;161(9):4702-8
pubmed: 9794400
Clin Cancer Res. 2021 Jul 1;27(13):3620-3629
pubmed: 33883177
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Trends Immunol. 2006 Aug;27(8):352-7
pubmed: 16807108
J Immunol. 2020 Apr 1;204(7):1988-1997
pubmed: 32094205
J Exp Med. 2003 Jan 20;197(2):263-8
pubmed: 12538665
Blood. 2004 Jun 15;103(12):4396-407
pubmed: 14551133
Protein Eng Des Sel. 2012 Oct;25(10):561-9
pubmed: 22740616
Blood. 2018 Mar 1;131(9):995-999
pubmed: 29305553
Transfusion. 2019 Jul;59(7):2248-2254
pubmed: 31183877
Lancet. 2015 Feb 7;385(9967):517-528
pubmed: 25319501
Immunol Rev. 2014 Jan;257(1):107-26
pubmed: 24329793
Haematologica. 2020 Jun;105(6):1494-1506
pubmed: 32482755
Lancet Oncol. 2015 Apr;16(4):375-84
pubmed: 25795410
Leukemia. 2009 May;23(5):934-43
pubmed: 19194466
MAbs. 2015;7(2):311-21
pubmed: 25760767
Genes (Basel). 2021 Jun 17;12(6):
pubmed: 34204358
J Med Chem. 2006 Jul 13;49(14):4392-408
pubmed: 16821799
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Arthritis Care Res (Hoboken). 2021 Sep;73(9):1372-1378
pubmed: 32475029
J Mol Graph Model. 2021 Sep;107:107949
pubmed: 34089985
Leukemia. 2010 Jun;24(6):1160-70
pubmed: 20428207
Clin Cancer Res. 2019 Dec 1;25(23):6986-6994
pubmed: 31685491
Nat Rev Drug Discov. 2006 Jun;5(6):471-84
pubmed: 16763660
Bone Marrow Res. 2012;2012:406796
pubmed: 22852088
Life Sci. 2015 Feb 1;122:59-64
pubmed: 25445480
Blood Cancer J. 2014 Jun 13;4:e218
pubmed: 24927407
Leukemia. 2009 Aug;23(8):1406-9
pubmed: 19282835
J Clin Invest. 2009 Dec;119(12):3502-11
pubmed: 19955661
Pediatr Blood Cancer. 2015 Jul;62(7):1171-5
pubmed: 25732247
J Immunol. 2018 Jan 15;200(2):459-468
pubmed: 29311388
J Hematol Oncol. 2018 Mar 15;11(1):41
pubmed: 29544528
Front Oncol. 2018 Nov 27;8:553
pubmed: 30538953
Clin Cancer Res. 2015 Sep 15;21(18):4035-9
pubmed: 26374073
Leukemia. 2014 May;28(5):1015-21
pubmed: 24166298
Lancet. 2014 Sep 20;384(9948):1109-17
pubmed: 25034862
Pediatr Hematol Oncol. 2019 Nov;36(8):468-481
pubmed: 31530240
Blood. 2009 Feb 12;113(7):1581-8
pubmed: 18974373
Blood. 2012 Oct 18;120(16):3187-205
pubmed: 22879540
Sci Transl Med. 2019 Feb 27;11(481):
pubmed: 30814337
Blood Cancer J. 2020 Jul 24;10(7):77
pubmed: 32709851
EMBO J. 1992 Nov;11(11):3887-95
pubmed: 1396582
J Pediatr Hematol Oncol. 2003 Aug;25(8):594-600
pubmed: 12902910
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
Pediatr Blood Cancer. 2019 Aug;66(8):e27765
pubmed: 31012549
Expert Rev Anticancer Ther. 2002 Feb;2(1):23-35
pubmed: 12113063
Pediatr Blood Cancer. 2019 Mar;66(3):e27542
pubmed: 30393935
J Immunother Cancer. 2019 Jul 10;7(1):175
pubmed: 31291985
Genes Chromosomes Cancer. 2009 Aug;48(8):637-60
pubmed: 19415723
J Leukoc Biol. 2009 Jun;85(6):939-46
pubmed: 19244164
Leukemia. 1994 Apr;8(4):535-41
pubmed: 8152248
Immunity. 2007 Oct;27(4):549-59
pubmed: 17967410
Leukemia. 2007 Feb;21(2):326-32
pubmed: 17205058
Clin Cancer Res. 2013 Apr 1;19(7):1795-805
pubmed: 23426279
Blood. 2021 Feb 11;137(6):751-762
pubmed: 32929488
Nat Genet. 2017 Aug;49(8):1211-1218
pubmed: 28671688
Arch Pathol Lab Med. 2020 Feb;144(2):150-155
pubmed: 31644323
Clin Transl Sci. 2019 Sep;12(5):428-430
pubmed: 31328862
Leukemia. 2017 Aug;31(8):1788-1797
pubmed: 27924074
Front Immunol. 2018 Nov 28;9:2722
pubmed: 30546360
Blood. 2017 Nov 9;130(19):2064-2072
pubmed: 28972016
Cancers (Basel). 2021 Jan 08;13(2):
pubmed: 33429845
J Immunol. 2006 Jul 1;177(1):362-71
pubmed: 16785532
J Clin Oncol. 2021 Oct 1;39(28):3149-3160
pubmed: 34048275
Asian Pac J Cancer Prev. 2020 Nov 01;21(11):3177-3183
pubmed: 33247673
Clin Cancer Res. 2001 Jun;7(6):1490-6
pubmed: 11410481
Int J Cancer. 1996 Sep 27;68(1):93-6
pubmed: 8895546
J Clin Invest. 2016 Jun 1;126(6):2123-38
pubmed: 27111235
Cell. 1997 Nov 14;91(4):501-10
pubmed: 9390559
JAMA. 2021 Mar 2;325(9):833-842
pubmed: 33651090
Immunol Rev. 2019 Jul;290(1):127-147
pubmed: 31355495
Cancer. 2007 Dec 15;110(12):2614-27
pubmed: 18000991
N Engl J Med. 2016 Aug 25;375(8):740-53
pubmed: 27292104
Cancer Discov. 2018 Sep;8(9):1069-1086
pubmed: 30115704
Front Pediatr. 2019 Nov 15;7:463
pubmed: 31803695
Biochemistry. 2019 Dec 3;58(48):4869-4881
pubmed: 31702909
EMBO Mol Med. 2017 Sep;9(9):1183-1197
pubmed: 28765140
Blood. 2008 Nov 15;112(10):3982-8
pubmed: 18780832
Blood. 2005 Jun 1;105(11):4247-54
pubmed: 15728125
Nature. 2014 Nov 27;515(7528):563-7
pubmed: 25428504
PLoS One. 2015 Sep 21;10(9):e0137345
pubmed: 26390038
Anticancer Drugs. 2002 Nov;13 Suppl 2:S3-10
pubmed: 12710585
Am Health Drug Benefits. 2016 Mar;9(Spec Feature):70-3
pubmed: 27668047
Int J Biochem Cell Biol. 2010 May;42(5):585-9
pubmed: 20060931
Br J Haematol. 2010 Aug;150(3):352-8
pubmed: 20528877
JAMA Oncol. 2020 Mar 1;6(3):375-384
pubmed: 31876895
Blood. 2007 Jun 15;109(12):5390-8
pubmed: 17327405
Clin Cancer Res. 2021 Mar 1;27(5):1242-1246
pubmed: 33234511
Blood Adv. 2020 Feb 11;4(3):449-457
pubmed: 32012214
Clin Interv Aging. 2009;4:197-205
pubmed: 19503782
Bioconjug Chem. 2006 Jan-Feb;17(1):114-24
pubmed: 16417259
Mol Ther Oncolytics. 2016 Apr 20;3:16011
pubmed: 27626062
Sci Rep. 2018 Jul 11;8(1):10479
pubmed: 29992976
Immunol Lett. 2016 Apr;172:113-23
pubmed: 26921100
Nature. 2001 Mar 29;410(6828):604-8
pubmed: 11279501
Ann Hematol. 2013 Aug;92(8):1071-7
pubmed: 23558906
Leukemia. 2000 May;14(5):853-8
pubmed: 10803517
JAMA. 2015 Sep 15;314(11):1113-4
pubmed: 26348357
Nat Genet. 2017 Mar;49(3):451-456
pubmed: 28112737
Nat Genet. 2015 Sep;47(9):1020-1029
pubmed: 26214592
Leukemia. 2019 Apr;33(4):884-892
pubmed: 30267011
Blood. 2005 Aug 15;106(4):1183-8
pubmed: 15886328
Best Pract Res Clin Haematol. 2020 Dec;33(4):101224
pubmed: 33279180
Nat Rev Clin Oncol. 2019 Sep;16(9):563-580
pubmed: 31092901
N Engl J Med. 2015 Sep 24;373(13):1207-19
pubmed: 26308596
Biomark Res. 2020 Feb 13;8:6
pubmed: 32082573
Leukemia. 2019 Dec;33(12):2854-2866
pubmed: 31110217
Cancer Discov. 2016 Jun;6(6):664-79
pubmed: 27076371
Leuk Lymphoma. 2006 Nov;47(11):2380-7
pubmed: 17107913
J Clin Med. 2021 Apr 29;10(9):
pubmed: 33946897
Blood. 2019 Aug 22;134(8):713-716
pubmed: 31311816
J Clin Oncol. 2016 Dec 20;34(36):4381-4389
pubmed: 27998223
Immunity. 2006 Jun;24(6):801-812
pubmed: 16782035
Haematologica. 2019 Aug;104(8):1633-1639
pubmed: 30733273
Clin Cancer Res. 2010 Sep 1;16(17):4331-8
pubmed: 20601446
Curr Hematol Malig Rep. 2020 Apr;15(2):83-89
pubmed: 32350732
Haematologica. 2011 Oct;96(10):1478-87
pubmed: 21791472
Cancers (Basel). 2020 Jul 20;12(7):
pubmed: 32698374
Blood. 2017 Oct 5;130(14):1620-1627
pubmed: 28983018
J Exp Med. 1991 Jul 1;174(1):139-49
pubmed: 1711560
Genes Immun. 2015 Jan-Feb;16(1):83-8
pubmed: 25427560
Cell. 2006 Feb 24;124(4):783-801
pubmed: 16497588
Blood. 2006 Nov 15;108(10):3302-4
pubmed: 16896151
Br J Haematol. 2009 Nov;147(4):585-7
pubmed: 19673881
Int J Cancer. 2005 May 20;115(1):98-104
pubmed: 15688411
Lancet Oncol. 2010 Feb;11(2):155-64
pubmed: 20004617
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Pediatr Blood Cancer. 2020 May;67(5):e28112
pubmed: 31944549
Cancer. 2005 Oct 1;104(7):1442-52
pubmed: 16116598
Nat Genet. 2015 Jun;47(6):672-6
pubmed: 25961940
EMBO Mol Med. 2016 Jul 01;8(7):702-11
pubmed: 27189167
J Clin Oncol. 2018 Aug 1;36(22):2306-2314
pubmed: 29812996
J Hematol Oncol. 2017 Mar 13;10(1):68
pubmed: 28288656
Leukemia. 2018 Feb;32(2):273-284
pubmed: 28701730
Nat Med. 2002 Aug;8(8):793-800
pubmed: 12091876
Cancer. 2006 Jun 15;106(12):2645-51
pubmed: 16688777
Pediatr Blood Cancer. 2019 Sep;66(9):e27873
pubmed: 31207026
J Clin Invest. 2020 Nov 2;130(11):6021-6033
pubmed: 32780725
Leuk Lymphoma. 2012 Oct;53(10):1999-2003
pubmed: 22448921
Nature. 2003 Aug 14;424(6950):743-8
pubmed: 12872135
Cytometry B Clin Cytom. 2020 Jul;98(4):336-347
pubmed: 32268011
Blood. 2019 Feb 14;133(7):697-709
pubmed: 30463995
Blood. 2004 Sep 15;104(6):1793-800
pubmed: 15172969
Mol Pharm. 2015 Jun 1;12(6):1703-16
pubmed: 25856201
Oncologist. 2008 Feb;13(2):167-74
pubmed: 18305062
Genes Chromosomes Cancer. 2014 Aug;53(8):667-75
pubmed: 24753324
Best Pract Res Clin Haematol. 2019 Dec;32(4):101097
pubmed: 31779968
Haematologica. 2001 Dec;86(12):1261-9
pubmed: 11726317
Physiol Rev. 2015 Jan;95(1):149-78
pubmed: 25540141
Science. 2017 Mar 31;355(6332):1423-1427
pubmed: 28280249
Biomark Res. 2017 Jun 24;5:22
pubmed: 28652918
Front Pharmacol. 2014 Oct 28;5:235
pubmed: 25389405
Cardiovasc Hematol Disord Drug Targets. 2019;19(3):195-204
pubmed: 31244444
Blood. 2009 Sep 17;114(12):2489-96
pubmed: 19528532
JAMA. 2021 Mar 2;325(9):843-854
pubmed: 33651091
Nat Immunol. 2003 Feb;4(2):161-7
pubmed: 12539043
J Mol Biol. 2006 Dec 15;364(5):945-54
pubmed: 17049554
Biochem Soc Trans. 2003 Jun;31(Pt 3):637-42
pubmed: 12773172
Blood. 2019 May 23;133(21):2291-2304
pubmed: 30796021
J Immunol. 2003 Oct 15;171(8):4304-10
pubmed: 14530355
Nature. 1987 Jul 16-22;328(6127):267-70
pubmed: 3496540
Lancet Haematol. 2021 Jan;8(1):e55-e66
pubmed: 33357483
Nat Immunol. 2012 Sep;13(9):832-42
pubmed: 22842346
J Crohns Colitis. 2017 Oct 1;11(10):1238-1246
pubmed: 28967957
Pediatr Blood Cancer. 2009 Dec;53(6):978-83
pubmed: 19637330
Yonsei Med J. 2016 Jan;57(1):5-14
pubmed: 26632377
Int Immunol. 2005 Jan;17(1):1-14
pubmed: 15585605
Eur J Haematol. 2021 Apr;106(4):473-483
pubmed: 33320384
JAMA Oncol. 2017 Sep 14;3(9):e172411
pubmed: 28817753
Blood. 2018 Oct 11;132(15):1584-1592
pubmed: 30150206
Gene Ther. 2010 Sep;17(9):1105-16
pubmed: 20428216
Nat Rev Immunol. 2020 Mar;20(3):173-185
pubmed: 31676858
Eur J Cancer. 2020 Mar;127:160-172
pubmed: 32028209
Shock. 2008 Mar;29(3):315-21
pubmed: 18277854
Drug Des Devel Ther. 2018 Jul 24;12:2293-2300
pubmed: 30087554
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Hematol Oncol. 2019 Jun;37 Suppl 1:95-100
pubmed: 31187533
Front Oncol. 2018 Sep 10;8:351
pubmed: 30250823
Cancer Metastasis Rev. 2019 Dec;38(4):595-610
pubmed: 31811553
J Clin Oncol. 2011 Jun 20;29(18):2493-8
pubmed: 21576633
Pediatr Blood Cancer. 2009 Feb;52(2):177-81
pubmed: 18816698
J Pediatr Hematol Oncol. 2009 Dec;31(12):936-41
pubmed: 19875969
Oncoimmunology. 2018 Feb 8;7(4):e1341032
pubmed: 29632712
Curr Drug Targets. 2017;18(3):296-303
pubmed: 25706110
Transplant Cell Ther. 2021 Sep;27(9):798.e1-798.e10
pubmed: 34111574
Int J Mol Sci. 2020 Jun 10;21(11):
pubmed: 32531894
Drug Des Devel Ther. 2014 Nov 17;8:2303-10
pubmed: 25429203
Cell. 2009 Jul 23;138(2):286-99
pubmed: 19632179
Clin Cancer Res. 2017 Mar 15;23(6):1506-1518
pubmed: 27663593
Pharmaceuticals (Basel). 2021 Jul 15;14(7):
pubmed: 34358100
Haematologica. 2019 Jan;104(1):120-127
pubmed: 30093401
Clin Cancer Res. 2009 Feb 1;15(3):832-9
pubmed: 19188153
J Trace Elem Med Biol. 2017 Dec;44:151-160
pubmed: 28965571
J Clin Oncol. 2019 Apr 1;37(10):770-779
pubmed: 30657737
Ann Neurol. 2018 Oct;84(4):537-546
pubmed: 30178481
Front Med. 2020 Dec;14(6):689-700
pubmed: 33074527
J Clin Oncol. 2008 Aug 1;26(22):3756-62
pubmed: 18669463
Science. 1989 May 12;244(4905):697-9
pubmed: 2717946
Drug Des Devel Ther. 2013 Dec 27;8:87-100
pubmed: 24403823
Blood. 2017 Jan 26;129(4):420-423
pubmed: 27903530
Crit Rev Biochem Mol Biol. 2015;50(3):212-30
pubmed: 25708195
Blood. 2011 Sep 29;118(13):3645-56
pubmed: 21813447
Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):139-45
pubmed: 26775883
J Exp Med. 2013 Dec 16;210(13):2903-19
pubmed: 24277153
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7
pubmed: 22451913
Drug Saf. 2015 May;38(5):455-79
pubmed: 25832756
N Engl J Med. 2016 Jul 14;375(2):143-53
pubmed: 27410923
Virology. 1999 Aug 15;261(1):120-32
pubmed: 10441560
Cancer. 2019 Jul 15;125(14):2474-2487
pubmed: 30920645
Haematologica. 2020 Jan 31;105(2):297-316
pubmed: 31753925
J Biol Chem. 2006 Sep 29;281(39):29054-63
pubmed: 16870615
MAbs. 2017 Feb/Mar;9(2):182-212
pubmed: 28071970
AIDS Treat News. 1997 Dec 5;(No 284):2-3
pubmed: 11364912
Lancet. 2020 Apr 4;395(10230):1146-1162
pubmed: 32247396
Biosci Rep. 2019 Apr 9;39(4):
pubmed: 30837326
Blood. 2021 Jun 10;137(23):3212-3217
pubmed: 33720354
Nat Immunol. 2003 Nov;4(11):1093-101
pubmed: 14556005
Cancer Growth Metastasis. 2015 Jul 23;8:25-34
pubmed: 26279628
Nat Rev Dis Primers. 2020 May 7;6(1):38
pubmed: 32382051
N Engl J Med. 2013 Jul 11;369(2):134-44
pubmed: 23724846
Blood. 2021 Mar 25;137(12):1582-1590
pubmed: 33067614
Drugs. 2018 Nov;78(16):1763-1767
pubmed: 30357593
J Immunother Cancer. 2020 Jun;8(1):
pubmed: 32581054
Blood Adv. 2020 Jul 28;4(14):3239-3245
pubmed: 32692850
Hum Gene Ther. 1995 Jun;6(6):813-9
pubmed: 7548281
Front Immunol. 2020 Jul 31;11:1710
pubmed: 32849603
Haematologica. 2007 Apr;92(4):519-32
pubmed: 17488663
J Clin Oncol. 2010 Jul 1;28(19):3167-75
pubmed: 20516446
Cancer Biol Ther. 2008 May;7(5):622-7
pubmed: 18756622
Clin Exp Immunol. 2018 Dec;194(3):295-314
pubmed: 30144037