Tocilizumab Trough Levels Variability in Kidney-Transplant Candidates Undergoing Desensitization.
desensitization
kidney-transplant
monoclonal antibodies
pharmacokinetic
tocilizumab
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Dec 2021
24 Dec 2021
Historique:
received:
05
11
2021
revised:
21
12
2021
accepted:
23
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
The presence of anti-HLA antibodies is an increasing challenge in kidney transplantation. Tocilizumab (TCZ), a monoclonal antibody targeting the interleukin-6 receptor (IL-6R), has been proposed to complement conventional desensitization therapy. We aimed to describe TCZ plasma trough concentrations and their variability and to investigate the link between TCZ concentration and the evolution of anti-HLA antibodies. Sensitized kidney-transplant candidates treated monthly with TCZ (8 mg/kg) for desensitization were retrospectively included. TCZ concentrations were determined by liquid chromatography-tandem mass spectrometry. Seventy-four TCZ concentrations from 10 patients were analyzed. The TCZ trough concentration ranged from <1.0 to 52.5 mg·L
Identifiants
pubmed: 35011830
pii: jcm11010091
doi: 10.3390/jcm11010091
pmc: PMC8745611
pii:
doi:
Types de publication
Journal Article
Langues
eng
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