Canonical (CD74/CD44) and Non-Canonical (CXCR2, 4 and 7) MIF Receptors Are Differentially Expressed in Rheumatoid Arthritis Patients Evaluated by DAS28-ESR.
DAS28
MIF
flow cytometry
inflammation
rheumatoid arthritis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 Dec 2021
27 Dec 2021
Historique:
received:
20
10
2021
revised:
13
12
2021
accepted:
21
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed to evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 and 7) expression and sCD74 to establish their association with RA clinical activity according to DAS28-ESR. 101 RA patients with different clinical activities (remission ( According to disease activity, CXCR7 expression (percentage of expression and mean fluorescence intensity (MFI)) was higher in granulocytes from patients in remission, while the expression of CXCR4 was higher in patients with high disease activity ( The results support the need for further study of the role of sCD74 as a soluble MIF decoy receptor, sequestering it to negatively regulate MIF signaling though its membrane receptors. The expression patterns of CXCR4 and CXCR7 show that the latter is a scavenger-type receptor that prevents endocytosis and even degradation of CXCR4 under inflammatory conditions.
Identifiants
pubmed: 35011861
pii: jcm11010120
doi: 10.3390/jcm11010120
pmc: PMC8745239
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : A1-S-8774
Références
BMC Rheumatol. 2018 Mar 23;2:8
pubmed: 30886959
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7917-E7926
pubmed: 27872288
Arthritis Rheum. 2002 Aug;46(8):2059-64
pubmed: 12209509
Front Immunol. 2018 Apr 03;9:633
pubmed: 29666622
Korean J Intern Med. 2016 Jul;31(4):634-42
pubmed: 27169879
Mol Pharmacol. 2019 Dec;96(6):809-818
pubmed: 31040166
Clin Immunol. 2021 Sep;230:108793
pubmed: 34242749
Cells. 2017 Feb 10;6(1):
pubmed: 28208600
Cell Signal. 2006 May;18(5):688-703
pubmed: 16122907
Curr Opin Cell Biol. 2014 Apr;27:72-7
pubmed: 24680433
Nat Rev Drug Discov. 2006 May;5(5):399-410
pubmed: 16628200
Ann Rheum Dis. 2012 Aug;71(8):1393-401
pubmed: 22532631
J Cell Sci. 2007 Jan 15;120(Pt 2):213-8
pubmed: 17215450
Cell Signal. 2019 May;57:76-88
pubmed: 30682543
FASEB J. 2015 Nov;29(11):4497-511
pubmed: 26139098
FEBS Lett. 2009 Sep 3;583(17):2749-57
pubmed: 19665027
Trends Immunol. 2019 May;40(5):447-462
pubmed: 30962001
Sci Rep. 2016 Jul 07;6:29338
pubmed: 27385284
Drug Discov Today. 2019 Feb;24(2):428-439
pubmed: 30439447
Hepatology. 2014 Feb;59(2):580-91
pubmed: 23913513
Front Immunol. 2015 Jul 21;6:373
pubmed: 26257740
Imaging Sci Dent. 2018 Mar;48(1):1-9
pubmed: 29581944
Nat Rev Dis Primers. 2018 Feb 08;4:18001
pubmed: 29417936
Sci Rep. 2018 Mar 26;8(1):5171
pubmed: 29581527
PLoS One. 2011 Jan 25;6(1):e16428
pubmed: 21283538
J Clin Rheumatol. 2015 Mar;21(2):57-62
pubmed: 25710855
Arthritis Rheum. 2010 Sep;62(9):2569-81
pubmed: 20872595
Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1269-81
pubmed: 27033518
Ann Rheum Dis. 1995 Jul;54(7):566-70
pubmed: 7545382