Urinary Tract Infections in Kidney Transplant Recipients-Is There a Need for Antibiotic Stewardship?
antibiotic stewardship
asymptomatic bacteriuria
fluoroquinolones
kidney transplantation
urinary tract infection
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
31 Dec 2021
31 Dec 2021
Historique:
received:
15
11
2021
revised:
19
12
2021
accepted:
21
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
(1) Background: Urinary tract infections (UTI) are the most common infections after kidney transplantation. Given the risk of urosepsis and the potential threat to the graft, the threshold for treating UTI and asymptomatic bacteriuria with broad spectrum antibiotics is low. Historically fluoroquinolones were prescription favorites for patients that underwent kidney transplantation (KT). After the recent recommendation to avoid them in these patients, however, alternative treatment strategies need to be investigated (2) Methods: We retrospectively analyzed the charts of 207 consecutive adult kidney transplantations that were performed at the department of General, Visceral and Transplantation Surgery of the University Hospital of Tuebingen between January 2015 and August 2020. All charts were screened for the diagnosis and treatment of asymptomatic bacteriuria (ASB) and urinary tract infections (UTI) and the patients' clinical characteristics and outcomes were evaluated. (3) Results: Of the 207 patients, 68 patients suffered from urinary tract infections. Patients who developed UTI had worse graft function at discharge (
Identifiants
pubmed: 35011966
pii: jcm11010226
doi: 10.3390/jcm11010226
pmc: PMC8745876
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Transplant Proc. 2020 May;52(4):1173-1177
pubmed: 32178929
Transplant Proc. 2020 Oct;52(8):2403-2408
pubmed: 32482447
Transpl Infect Dis. 2017 Dec;19(6):
pubmed: 28803446
Transpl Infect Dis. 2014 Apr;16(2):261-9
pubmed: 24621104
Clin Microbiol Infect. 2021 Mar;27(3):398-405
pubmed: 32919076
Exp Clin Transplant. 2020 Jun;18(3):306-312
pubmed: 31424358
Clin Transplant. 2017 May;31(5):
pubmed: 28295630
Clin Transplant. 2019 Mar;33(3):e13491
pubmed: 30697807
Clin Infect Dis. 2019 May 2;68(10):e83-e110
pubmed: 30895288
Transpl Infect Dis. 2020 Jun;22(3):e13261
pubmed: 32037682
Eur Urol Focus. 2018 Mar;4(2):208-215
pubmed: 30033070
PLoS One. 2019 Sep 6;14(9):e0221820
pubmed: 31490951
Transplantation. 2013 Oct 27;96(8):732-8
pubmed: 23917724
Can J Kidney Health Dis. 2018 Sep 12;5:2054358118799692
pubmed: 30224973
Transpl Infect Dis. 2018 Apr;20(2):e12828
pubmed: 29272071
Transplant Proc. 2018 Dec;50(10):3351-3355
pubmed: 30577206
Nephrol Dial Transplant. 2018 Sep 1;33(9):1661-1668
pubmed: 29635410
Am J Transplant. 2020 Feb;20(2):451-462
pubmed: 31550408
Clin Transplant. 2014 Jun;28(6):683-90
pubmed: 24654771
Am J Infect Control. 2016 Nov 1;44(11):1261-1268
pubmed: 27311513
Nephrol Dial Transplant. 2020 Nov 1;35(11):1996-2003
pubmed: 31883327
BMC Infect Dis. 2016 Feb 25;16:90
pubmed: 26912326
Adv Chronic Kidney Dis. 2020 Jan;27(1):31-37
pubmed: 32146999
Clin Microbiol Infect. 2015 Dec;21(12):1104.e1-8
pubmed: 26235196
Nephrol Dial Transplant. 2014 Feb;29(2):260-2
pubmed: 24203811
Eur J Clin Microbiol Infect Dis. 1991 Apr;10(4):342-50
pubmed: 1864295
Transpl Infect Dis. 2012 Dec;14(6):595-603
pubmed: 22650416
Transplantation. 2019 Jun;103(6):1272-1276
pubmed: 30130327
Int J Antimicrob Agents. 1994 Jul;4 Suppl 2:S29-37
pubmed: 18611630
J Clin Med. 2019 May 16;8(5):
pubmed: 31100847
J Clin Microbiol. 2020 Apr 23;58(5):
pubmed: 32051261
Transplant Proc. 2017 Mar;49(2):297-302
pubmed: 28219588
J Nephrol. 2019 Aug;32(4):661-668
pubmed: 30701457
Can Urol Assoc J. 2017 Sep;11(9):E350-E354
pubmed: 29382457
Int J Urol. 2019 Jan;26(1):69-74
pubmed: 30221416
Clin Infect Dis. 2020 Oct 23;71(7):e159-e169
pubmed: 31915816
Expert Opin Pharmacother. 2018 Jun;19(9):979-992
pubmed: 29877755
Curr Opin Urol. 2021 Jul 1;31(4):285-290
pubmed: 34009175
Transplant Proc. 2017 Oct;49(8):1757-1765
pubmed: 28923621
Transpl Infect Dis. 2020 Feb;22(1):e13221
pubmed: 31782870
Clin Transplant. 2019 Jun;33(6):e13583
pubmed: 31038773
Cochrane Database Syst Rev. 2018 Feb 01;2:CD011357
pubmed: 29390169
Infect Control Hosp Epidemiol. 2016 Dec;37(12):1468-1474
pubmed: 27692005
Clin Transplant. 1997 Oct;11(5 Pt 1):446-52
pubmed: 9361939
Pharmacotherapy. 1988;8(1):3-33
pubmed: 2836821
Transplant Proc. 2017 Nov;49(9):2070-2075
pubmed: 29149963
Ann Transplant. 2013 May 06;18:195-204
pubmed: 23792521
World J Urol. 2019 May;37(5):957-967
pubmed: 30109484
Transplant Proc. 2014 Dec;46(10):3463-5
pubmed: 25498073
Surgery. 2015 Jan;157(1):104-10
pubmed: 25304836
Am J Transplant. 2016 Oct;16(10):2943-2953
pubmed: 27088545