Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
celiac disease
clinical presentation
diagnosis
extraintestinal
gluten-free diet
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
04 Jan 2022
04 Jan 2022
Historique:
received:
24
11
2021
revised:
24
12
2021
accepted:
30
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient's prognosis.
Identifiants
pubmed: 35011999
pii: jcm11010258
doi: 10.3390/jcm11010258
pmc: PMC8746138
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Neth J Med. 2009 Dec;67(11):376-87
pubmed: 20009114
Eur Oral Res. 2018 Sep;52(3):150-156
pubmed: 30775719
J Clin Diagn Res. 2015 Apr;9(4):OD01-3
pubmed: 26023582
Scand J Gastroenterol. 1988 Oct;23(8):1000-4
pubmed: 3201123
Nutrients. 2020 Mar 20;12(3):
pubmed: 32244870
Arch Neurol. 2006 Oct;63(10):1440-6
pubmed: 17030661
Am J Gastroenterol. 2010 Mar;105(3):691-6
pubmed: 19904244
JAMA Pediatr. 2015 Mar;169(3):e1525
pubmed: 25730696
Ginekol Pol. 1999 May;70(5):359-62
pubmed: 10462981
Vnitr Lek. 2010 Nov;56(11):1169-76
pubmed: 21250496
ScientificWorldJournal. 2014;2014:614269
pubmed: 24895657
Dig Dis. 1994 May-Jun;12(3):186-90
pubmed: 7988065
Pediatr Endocrinol Rev. 2009 Jun;6(4):457-63
pubmed: 19550380
Am J Gastroenterol. 2016 Apr;111(4):561-7
pubmed: 26832652
Nutrients. 2018 Oct 06;10(10):
pubmed: 30301194
AJNR Am J Neuroradiol. 1995 Aug;16(7):1498-500
pubmed: 7484640
Acta Neurol Belg. 2018 Mar;118(1):21-27
pubmed: 29247390
Clin Chim Acta. 2010 Jul 4;411(13-14):931-5
pubmed: 20171961
Front Neurosci. 2017 Sep 05;11:498
pubmed: 28928632
Gut. 1996 Sep;39(3):382-4
pubmed: 8949641
Clin Endocrinol (Oxf). 2016 Apr;84(4):578-86
pubmed: 26147910
Lancet. 1969 Dec 20;2(7634):1366
pubmed: 4188128
Lancet. 1996 Feb 10;347(8998):369-71
pubmed: 8598704
J Psychosom Res. 2013 Feb;74(2):155-60
pubmed: 23332531
Neurology. 2012 May 1;78(18):1401-7
pubmed: 22517096
Arch Pediatr. 2021 Feb;28(2):105-110
pubmed: 33341334
Medicina (Kaunas). 2019 Sep 09;55(9):
pubmed: 31505858
Front Pediatr. 2019 Mar 05;7:56
pubmed: 30891436
J Neurol Sci. 1982 Jan;53(1):9-22
pubmed: 7057204
Lancet. 1992 Aug 22;340(8817):439-43
pubmed: 1354781
Eur J Gastroenterol Hepatol. 2013 Sep;25(9):1033-7
pubmed: 23743561
Neurol Sci. 2003 Dec;24(5):311-7
pubmed: 14716525
J Oral Facial Pain Headache. 2019 Mar 20;33(3):294–300
pubmed: 30893404
J Gastroenterol Hepatol. 2021 Jan;36(1):44-54
pubmed: 32621396
Aliment Pharmacol Ther. 2011 Jul;34(1):33-40
pubmed: 21545472
Clin Gastroenterol Hepatol. 2019 Dec;17(13):2678-2686.e2
pubmed: 30885888
Nutrients. 2020 Jan 04;12(1):
pubmed: 31947912
J Neurol Neurosurg Psychiatry. 2004 Nov;75(11):1623-5
pubmed: 15489401
World J Gastroenterol. 2016 Oct 14;22(38):8472-8479
pubmed: 27784959
Immunity. 2012 Jun 29;36(6):907-19
pubmed: 22749351
Gut. 2013 Jan;62(1):43-52
pubmed: 22345659
Nutrients. 2020 Mar 28;12(4):
pubmed: 32231050
Mov Disord. 2010 Apr 30;25(6):799-800
pubmed: 20437547
Br J Dermatol. 1997 May;136(5):801-2
pubmed: 9205530
Panminerva Med. 2011 Dec;53(4):213-6
pubmed: 22146418
Aliment Pharmacol Ther. 2014 Nov;40(10):1123-32
pubmed: 25270960
J Am Acad Dermatol. 2014 Aug;71(2):350-8
pubmed: 24780176
Gastroenterology. 2002 Apr;122(4):881-8
pubmed: 11910339
J Dent. 2017 Oct;65:1-10
pubmed: 28688949
J Atten Disord. 2006 Nov;10(2):200-4
pubmed: 17085630
Hum Reprod Update. 2014 Jul-Aug;20(4):582-93
pubmed: 24619876
J Clin Endocrinol Metab. 2007 Sep;92(9):3595-8
pubmed: 17595243
Iran J Reprod Med. 2011 Spring;9(2):135-40
pubmed: 25587261
Med Hypotheses. 2009 Sep;73(3):438-40
pubmed: 19406584
N Engl J Med. 2011 Feb 24;364(8):783-4; author reply 784
pubmed: 21345123
Ann Hepatol. 2013 May-Jun;12(3):501-5
pubmed: 23619270
Arch Dis Child. 2004 Sep;89(9):882-3
pubmed: 15321874
Gastroenterol Res Pract. 2014;2014:934159
pubmed: 25197270
Liver Int. 2021 Nov;41(11):2693-2702
pubmed: 34219350
Brain. 1966 Dec;89(4):683-722
pubmed: 4163580
Open Dent J. 2017 Oct 24;11:539-545
pubmed: 29238414
Nutrients. 2019 Feb 12;11(2):
pubmed: 30759885
Ann Gastroenterol. 2015 Apr-Jun;28(2):236-240
pubmed: 25831067
J Clin Gastroenterol. 2020 Jan;54(1):8-21
pubmed: 31513026
Nutrients. 2018 Jun 21;10(7):
pubmed: 29933630
Gastroenterology. 2005 Apr;128(4):849-55
pubmed: 15825068
Acta Psychiatr Scand. 2012 Mar;125(3):189-93
pubmed: 22128768
Physiol Behav. 2009 Aug 4;98(1-2):156-62
pubmed: 19454292
J Clin Gastroenterol. 2016 Jan;50(1):33-9
pubmed: 25564410
Dig Dis Sci. 1982 Mar;27(3):269-73
pubmed: 7075423
Schizophr Res. 2001 Apr 15;49(1-2):73-8
pubmed: 11343866
Gut. 1983 Feb;24(2):127-35
pubmed: 6682819
Horm Res Paediatr. 2014;81(5):309-13
pubmed: 24603159
Br Med J. 1978 Mar 4;1(6112):537-9
pubmed: 630212
Scand J Gastroenterol. 1982 Jan;17(1):65-8
pubmed: 7134839
J Neurol Neurosurg Psychiatry. 2003 Apr;74(4):490-4
pubmed: 12640070
Minerva Gastroenterol Dietol. 2016 Jun;62(2):197-206
pubmed: 26619901
Eur J Gastroenterol Hepatol. 2018 Jul;30(7):806-807
pubmed: 29847525
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):885-9
pubmed: 8350105
Reprod Med Biol. 2021 Mar 22;20(2):224-233
pubmed: 33850456
Gut. 2014 Aug;63(8):1210-28
pubmed: 24917550
Acta Biomed. 2018 Mar 27;89(1):117-121
pubmed: 29633735
Hepat Mon. 2011 May;11(5):333-41
pubmed: 22087157
Diabetol Metab Syndr. 2016 Jul 29;8:51
pubmed: 27478507
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Aug;124(2):152-156
pubmed: 28756881
Nutrients. 2018 Aug 03;10(8):
pubmed: 30081502
Nutr Res Rev. 2017 Jun;30(1):25-35
pubmed: 27976606
Scand J Gastroenterol. 2001 May;36(5):502-6
pubmed: 11346203
Nutrients. 2018 May 12;10(5):
pubmed: 29757210
J Clin Neuromuscul Dis. 2012 Mar;13(3):137-45
pubmed: 22538308
Nutrients. 2019 Aug 20;11(8):
pubmed: 31434238
Scand J Gastroenterol. 2003 May;38(5):511-5
pubmed: 12795461
Dig Dis. 2015;33(2):147-154
pubmed: 25925916