Cognitive Impairment in People with Epilepsy.
EEG
anti-epileptic drugs
cognitive impairment
epilepsy
memory deficits
seizures
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
05 Jan 2022
05 Jan 2022
Historique:
received:
15
11
2021
revised:
18
12
2021
accepted:
30
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
12
1
2022
Statut:
epublish
Résumé
People with epilepsy frequently have cognitive impairment. The majority of cognitive problems is influenced by a variety of interlinked factors, including the early onset of epilepsy and the frequency, intensity and duration of seizures, along with the anti-epileptic drug treatment. With a systematic review, we investigate significant factors about the cognitive impairment in epilepsy. Most cognitive problems in adult people with epilepsy include memory, attention and executive function deficits. However, which cognitive area is mainly affected highly depends on the location of epileptic activity. Moreover, modifications in signalling pathways and neuronal networks have an essential role in both the pathophysiology of epilepsy and in the mechanism responsible for cognitive impairment. Additionally, studies have shown that the use of polytherapy in the treatment of epilepsy with anti-epileptic drugs (AEDs) heightens the risk for cognitive impairment. It can be challenging to distinguish the contribution of each factor, because they are often closely intertwined.
Identifiants
pubmed: 35012007
pii: jcm11010267
doi: 10.3390/jcm11010267
pmc: PMC8746065
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : University Medical Centre Maribor, Maribor, Slovenia
ID : IRP-2018/01-21
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