Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.
4-Nitroquinoline-1-oxide
/ toxicity
Antineoplastic Agents
/ metabolism
Carcinogens
/ toxicity
Cell Line, Tumor
Dendritic Cells
/ drug effects
Epithelial Cells
/ metabolism
Epithelium
/ drug effects
Gene Expression Regulation, Neoplastic
/ drug effects
Head and Neck Neoplasms
/ genetics
Histones
/ metabolism
Humans
Immunity
/ drug effects
Langerhans Cells
/ drug effects
Phagocytes
/ drug effects
Quinolones
/ toxicity
Squamous Cell Carcinoma of Head and Neck
/ genetics
T-Lymphocytes, Regulatory
/ drug effects
Tongue
/ pathology
Transcriptome
/ genetics
4NQO
Langerhans cells
oral cancer
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 01 2022
18 01 2022
Historique:
accepted:
10
11
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
23
2
2022
Statut:
ppublish
Résumé
Early diagnosis of oral squamous cell carcinoma (OSCC) remains an unmet clinical need. Therefore, elucidating the initial events of OSCC preceding tumor development could benefit OSCC prognosis. Here, we define the Langerhans cells (LCs) of the tongue and demonstrate that LCs protect the epithelium from carcinogen-induced OSCC by rapidly priming αβT cells capable of eliminating γH2AX
Identifiants
pubmed: 35012988
pii: 2118424119
doi: 10.1073/pnas.2118424119
pmc: PMC8784117
pii:
doi:
Substances chimiques
4-nitroquinolone-1-oxide
0
Antineoplastic Agents
0
Carcinogens
0
H2AX protein, human
0
Histones
0
Quinolones
0
4-Nitroquinoline-1-oxide
56-57-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2022 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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