Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
09
06
2021
accepted:
26
10
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
21
1
2022
Statut:
epublish
Résumé
The emergence of distributed patterns of neural activity supporting brain functions and behavior can be understood by study of the brain's low-dimensional topology. Functional neuroimaging demonstrates that brain activity linked to adaptive behavior is constrained to low-dimensional manifolds. In human participants, we tested whether these low-dimensional constraints preserve working memory performance following local neuronal perturbations. We combined multi-session functional magnetic resonance imaging, non-invasive transcranial magnetic stimulation (TMS), and methods translated from the fields of complex systems and computational biology to assess the functional link between changes in local neural activity and the reshaping of task-related low dimensional trajectories of brain activity. We show that specific reconfigurations of low-dimensional trajectories of brain activity sustain effective working memory performance following TMS manipulation of local activity on, but not off, the space traversed by these trajectories. We highlight an association between the multi-scale changes in brain activity underpinning cognitive function.
Identifiants
pubmed: 35013147
doi: 10.1038/s41467-021-26978-2
pii: 10.1038/s41467-021-26978-2
pmc: PMC8749005
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4Subventions
Organisme : NINDS NIH HHS
ID : F32 NS090757
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103556
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH063901
Pays : United States
Informations de copyright
© 2022. The Author(s).
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