Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.

Antibodies, Neutralizing / immunology Antibodies, Viral / immunology BNT162 Vaccine / administration & dosage COVID-19 / immunology Convalescence Cytokines / immunology Flow Cytometry / methods Follow-Up Studies Humans Immunoglobulin G / immunology Interleukin-2 / immunology Kinetics Nucleocapsid / immunology SARS-CoV-2 / immunology Spike Glycoprotein, Coronavirus / immunology T-Lymphocytes / immunology Time Factors Vaccination / methods

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
10 01 2022

Historique:

received: 06 09 2021

accepted: 02 12 2021

entrez: 11 1 2022

pubmed: 12 1 2022

medline: 27 1 2022

Statut: epublish

Résumé

Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we characterize the dynamics of anti-viral immunity during long-term follow-up and after BNT162b2 mRNA-vaccination in convalescents after asymptomatic or mild SARS-CoV-2 infection. Virus-specific and virus-neutralizing antibody titers rapidly declined in convalescents over 9 months after infection, whereas virus-specific cytokine-producing polyfunctional T cells persisted, among which IL-2-producing T cells correlated with virus-neutralizing antibody titers. Among convalescents, 5% of individuals failed to mount long-lasting immunity after infection and showed a delayed response to vaccination compared to 1% of naïve vaccinees, but successfully responded to prime/boost vaccination. During the follow-up period, 8% of convalescents showed a selective increase in virus-neutralizing antibody titers without accompanying increased frequencies of circulating SARS-CoV-2-specific T cells. The same convalescents, however, responded to vaccination with simultaneous increase in antibody and T cell immunity revealing the strength of mRNA-vaccination to increase virus-specific immunity in convalescents.

Identifiants

DOI: 10.1038/s41467-021-27649-y PMID: 35013191 PMC: PMC8748966

pubmed: 35013191

doi: 10.1038/s41467-021-27649-y

pii: 10.1038/s41467-021-27649-y

pmc: PMC8748966

doi:

Substances chimiques

Antibodies, Neutralizing 0

Antibodies, Viral 0

Cytokines 0

Immunoglobulin G 0

Interleukin-2 0

Spike Glycoprotein, Coronavirus 0

spike protein, SARS-CoV-2 0

BNT162 Vaccine N38TVC63NU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

153

Subventions

Organisme : Deutsches Zentrum für Infektionsforschung (German Center for Infection Research)

ID : Munich site

Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)

ID : SFB TRR 179

Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)

ID : SFB TRR 179

Organisme : Bayerische Forschungsstiftung (Bavarian Research Foundation)

ID : CoVRAPID

Organisme : Bayerische Forschungsstiftung (Bavarian Research Foundation)

ID : CoVRapid

Organisme : Helmholtz Association

ID : COVIPA

Organisme : Helmholtz Association

ID : COVIPA

Organisme : State Ministry of Education and Culture, Science and the Arts | Elitenetzwerk Bayern (Elite Network of Bavaria)

ID : ForCOVID

Organisme : State Ministry of Education and Culture, Science and the Arts | Elitenetzwerk Bayern (Elite Network of Bavaria)

ID : ForCovid

Informations de copyright

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