Prenatal origins of suicide mortality: A prospective cohort study in the United States.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
04
08
2021
accepted:
20
12
2021
revised:
07
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
1
2
2022
Statut:
epublish
Résumé
Most suicide research focuses on acute precipitants and is conducted in high-risk populations. Yet, vulnerability to suicide is likely established years prior to its occurrence. In this study, we aimed to investigate the risk of suicide mortality conferred by prenatal sociodemographic and pregnancy-related factors. Offspring of participants (N = 49,853) of the Collaborative Perinatal Project, a U.S. population-based cohort of pregnancies enrolled between 1959 and 1966, were linked to the U.S. National Death Index to determine their vital status by the end 2016. We examined associations between sociodemographic factors during pregnancy, pregnancy complications, labor and delivery complications, and neonatal complications with suicide death coded according to ICD-9/10 criteria. By the end of 2016, 3,555 participants had died. Of these, 288 (214 males, 74 females) died by suicide (incidence rate = 15.6 per 100,000 person-years, 95% Confidence Interval [CI] = 13.9-17.5). In adjusted models, male sex (Hazard Ratio [HR] = 2.98, CI: 2.26-3.93), White race (HR = 2.14, CI = 1.63-2.83), low parental education (HR = 2.23, CI = 1.38-3.62), manual parental occupation (HR = 1.38, CI = 1.05-1.82), being a younger sibling (HR = 1.52, CI = 1.10-2.11), higher rates of pregnancy complications (HR = 2.36, CI = 1.08-5.16), and smoking during pregnancy (HR = 1,28, CI = 0.99-1.66) were independently associated with suicide risk, whereas birth and neonatal complications were not. Consistent with the developmental origins of psychiatric disorders, vulnerability to suicide mortality is established early in development. Both sociodemographic and pregnancy factors play a role in this risk, which underscores the importance of considering life course approaches to suicide prevention, possibly including provision of high-quality prenatal care, and alleviating the socioeconomic burdens of mothers and families.
Identifiants
pubmed: 35013255
doi: 10.1038/s41398-021-01777-x
pii: 10.1038/s41398-021-01777-x
pmc: PMC8748551
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14Informations de copyright
© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
Références
J Youth Adolesc. 1989 Apr;18(2):175-90
pubmed: 24271685
Brain Behav Immun. 2009 Oct;23(7):905-16
pubmed: 19217937
Eur J Epidemiol. 2012 Sep;27(9):729-38
pubmed: 22911024
Am J Epidemiol. 1984 May;119(5):837-9
pubmed: 6720679
Acta Psychiatr Scand. 2018 Feb;137(2):116-124
pubmed: 29270976
Psychol Med. 2014 Apr;44(6):1245-56
pubmed: 23895695
Am J Public Health. 1983 Nov;73(11):1265-9
pubmed: 6625029
BMJ. 1998 Nov 14;317(7169):1346-9
pubmed: 9812930
Br J Psychiatry. 1978 Dec;133:542-9
pubmed: 737391
Am J Epidemiol. 2014 Jun 15;179(12):1450-7
pubmed: 24824986
Drug Alcohol Depend. 2008 Jun 1;95 Suppl 1:S60-73
pubmed: 18329189
Am J Epidemiol. 1993 Jan 15;137(2):235-41
pubmed: 8452128
Lancet Psychiatry. 2020 May;7(5):399-410
pubmed: 32220288
Ann Epidemiol. 2002 Oct;12(7):462-8
pubmed: 12377423
Int J Epidemiol. 2021 Nov 10;50(5):1604-1614
pubmed: 33693753
BMC Pregnancy Childbirth. 2014 Mar 04;14:96
pubmed: 24589212
Soc Sci Med. 2016 Jun;158:8-13
pubmed: 27100213
Am J Epidemiol. 2007 Jan 1;165(1):85-93
pubmed: 17041134
Psychol Med. 2022 May;52(7):1255-1267
pubmed: 33019954
Asia Pac J Public Health. 1995;8(3):181-5
pubmed: 10050186
Curr Psychiatry Rep. 2017 Jan;19(1):1
pubmed: 28091799
Curr Psychiatry Rep. 2016 Sep;18(9):86
pubmed: 27484207
J Epidemiol Community Health. 2010 May;64(5):407-12
pubmed: 19679707
Obstet Gynecol. 2011 Apr;117(4):978-985
pubmed: 21422872
Eur J Epidemiol. 2011 Jul;26(7):571-81
pubmed: 21681547
JAMA. 1997 Aug 27;278(8):637-43
pubmed: 9272895
J Epidemiol Community Health. 2008 Jan;62(1):23-8
pubmed: 18079329
Stat Med. 2020 Apr 15;39(8):1199-1236
pubmed: 31985089
Am J Epidemiol. 2013 Apr 1;177(7):638-44
pubmed: 23479347
Soc Psychiatry Psychiatr Epidemiol. 2012 Nov;47(11):1783-94
pubmed: 22327374
Int Rev Neurobiol. 2020;152:101-130
pubmed: 32450993
Eur Child Adolesc Psychiatry. 2018 Jan;27(1):47-56
pubmed: 28664290
Br J Psychiatry. 2005 Sep;187:206-8
pubmed: 16135856
Am J Public Health. 2017 Aug;107(8):1233-1239
pubmed: 28640689
J Child Psychol Psychiatry. 2011 Apr;52(4):356-67
pubmed: 21250994
Eur J Epidemiol. 2011 Jun;26(6):485-92
pubmed: 21331660
Am J Psychiatry. 2020 Oct 1;177(10):928-935
pubmed: 32854532
J Child Psychol Psychiatry. 2021 Sep;62(9):1050-1066
pubmed: 33259072
Psychol Med. 2015 Apr;45(5):985-99
pubmed: 25191989
Am J Psychiatry. 2017 Apr 1;174(4):319-328
pubmed: 27838934
Adv Life Course Res. 2014 Dec;22:49-61
pubmed: 26047691
Child Care Health Dev. 2012 Sep;38(5):611-28
pubmed: 22372737
Healthcare (Basel). 2016 Jun 01;4(2):
pubmed: 27417618
J Affect Disord. 2020 Dec 1;277:914-926
pubmed: 33065834
Acta Psychiatr Scand. 1998 Jun;97(6):412-8
pubmed: 9669512
Lancet. 1985 Mar 16;1(8429):624-7
pubmed: 2857957
Ann N Y Acad Sci. 2008;1136:80-5
pubmed: 17954684
BMC Psychiatry. 2015 Aug 14;15:196
pubmed: 26271258
J Dev Orig Health Dis. 2014 Oct;5(5):339-50
pubmed: 25081923
J Nerv Ment Dis. 2010 Jun;198(6):404-11
pubmed: 20531118
Am J Med Genet C Semin Med Genet. 2005 Feb 15;133C(1):13-24
pubmed: 15648081
Psychol Bull. 2017 Feb;143(2):187-232
pubmed: 27841450
Trends Neurosci. 2012 Jan;35(1):14-23
pubmed: 22177979
PLoS One. 2016 Mar 24;11(3):e0150486
pubmed: 27010541
Int J Epidemiol. 2013 Oct;42(5):1381-9
pubmed: 23920142
JAMA Psychiatry. 2013 Nov;70(11):1231-40
pubmed: 24068297
Arch Gen Psychiatry. 1999 Jul;56(7):617-26
pubmed: 10401507
Schizophr Res. 2010 Aug;121(1-3):218-26
pubmed: 20163936
Vital Health Stat 10. 1997 Jul;(196):1-46
pubmed: 9230651
Psychol Med. 2008 Aug;38(8):1203-10
pubmed: 18047770
Lancet Psychiatry. 2019 Jun;6(6):477-492
pubmed: 31029623
Int J Behav Dev. 2013 Jul 1;37(4):366-375
pubmed: 24839336
Scand J Psychol. 2009 Dec;50(6):583-91
pubmed: 19930257
Br J Psychiatry. 2021 Sep;219(3):507-514
pubmed: 33583444
Br J Psychiatry. 2006 Dec;189:502-7
pubmed: 17139033
Int J Soc Psychiatry. 2013 Sep;59(6):545-54
pubmed: 22582346
J Chronic Dis. 1986;39(9):719-34
pubmed: 3734026
Behav Genet. 2016 May;46(3):334-52
pubmed: 27075497
Acta Psychiatr Scand. 1998 Sep;98(3):214-8
pubmed: 9761408