DNA methylation aging and transcriptomic studies in horses.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 01 2022
10 01 2022
Historique:
received:
16
05
2021
accepted:
07
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we profile n = 333 samples from 42 horse tissue types at loci that are highly conserved between mammalian species using a custom array (HorvathMammalMethylChip40). Using the blood and liver tissues from horses, we develop five epigenetic aging clocks: a multi-tissue clock, a blood clock, a liver clock and two dual-species clocks that apply to both horses and humans. In addition, using blood methylation data from three additional equid species (plains zebra, Grevy's zebras and Somali asses), we develop another clock that applies across all equid species. Castration does not significantly impact the epigenetic aging rate of blood or liver samples from horses. Methylation and RNA data from the same tissues define the relationship between methylation and RNA expression across horse tissues. We expect that the multi-tissue atlas will become a valuable resource.
Identifiants
pubmed: 35013267
doi: 10.1038/s41467-021-27754-y
pii: 10.1038/s41467-021-27754-y
pmc: PMC8748428
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
40Subventions
Organisme : NIH HHS
ID : K01 OD015134
Pays : United States
Organisme : NCATS NIH HHS
ID : L40 TR001136
Pays : United States
Informations de copyright
© 2022. The Author(s).
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