Egocentric spatial orientation differences between Alzheimer's disease at early stages and mild cognitive impairment: a diagnostic aid.
Alzheimer’s disease
Dementia
Mild cognitive impairment
Spatial orientation
Virtual reality
Journal
Medical & biological engineering & computing
ISSN: 1741-0444
Titre abrégé: Med Biol Eng Comput
Pays: United States
ID NLM: 7704869
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
23
02
2021
accepted:
24
11
2021
pubmed:
12
1
2022
medline:
21
1
2022
entrez:
11
1
2022
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a growing global crisis. Egocentric spatial orientation deteriorates with age and more significantly with AD. A simple and quick virtual reality (VR) localization and target finding technique is presented as a diagnostic aid to screen mild cognitive impairment (MCI) from AD. Spatial orientation data from 93 individuals (65 AD at a mild stage, 20 MCI, and 8 other dementia types) based on VR localization of a target on a landmark-less cubic 3-story building were analyzed. We hypothesize AD and MCI groups' performances are significantly different. AD and MCI spatial performances were statistically significantly (p < 0.001) different. These results plus the longitudinal tracking of three patients who developed AD over a period of 5 years suggest the proposed spatial tests may be used as a quick and simple clinical diagnostic aid to separate AD at early to mild stages from MCI.
Identifiants
pubmed: 35013869
doi: 10.1007/s11517-021-02478-9
pii: 10.1007/s11517-021-02478-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
501-509Informations de copyright
© 2021. International Federation for Medical and Biological Engineering.
Références
Nichols E, e. al, Murray C (2019) Global, regional and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(1):8
DeTrue M, Dickson D (2019) The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener 14(32)
Ranjbar-Pooya O et al (2017) Introducing a new age-and-cognition-sensitive measurement for assessing spatial orientation using a landmark-less virtual reality navigational task. Q J Exp Psychol 70(7):15
Moffat S et al (2007) Extrahippocampal contributions to age differences in human spatial navigation. Cereb Cortex 17:1274–1282
doi: 10.1093/cercor/bhl036
De Leonibus E, Oliverio A, Mele A (2005) A study on the role of the dorsal striatum and the nucleus accumbens in allocentric and egocentric spatial memory consolidation. Learn Mem 12(5):491–503
doi: 10.1101/lm.94805
Raz N et al (2003) Differential aging of the human striatum: longitudinal evidence. Am J Neuroradiol 24:1849–1856
pubmed: 14561615
pmcid: 7976312
Nasreddine ZS et al (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):4
doi: 10.1111/j.1532-5415.2005.53221.x
Schrag A, Schott JM (2012) What is the clinically relevant change on the ADAS-Cog? Neurol Neurosurg Pscyhiatry 83:171–173
doi: 10.1136/jnnp-2011-300881
Cherrier MM, Mendez M, Perryman K (2001) Route learning performance in Alzheimer disease patients. Neuropsychiatr Neuropsychol Behav Neuro 14(3):159–68
Schiza E et al (2019) Virtual reality applications for neurological disease: a review. Front Robot AI 6(100)
Aldaba C, Moussavi Z (2020) Effects of virtual reality technology locomotive multi-sensory motion stimuli on a user simulator sickness and controller intuitiveness during a navigation task. J Med Biol Eng Comput 58:143–154
doi: 10.1007/s11517-019-02070-2
Borghi A, Cimatti F (2010) Embodied cognition and beyond. Neuropsychiatr Dis Treat 48(3):763–773
Glenberg AM et al (2005) Grounding language in bodily states: the case for emotion. In: Pecher D, Zwaan RA (eds) grounding cognition: the role of perception and action in memory, language, and thinking. Cambridge University Press, Cambridge, pp 115–128
doi: 10.1017/CBO9780511499968.006
Kimura K et al (2017) Orientation in virtual reality does not fully measure up to the real-world. Sci Rep 7(1):18109
doi: 10.1038/s41598-017-18289-8
Byagowi A, Mohaddes D, Moussavi Z (2014) Design and application of a novel virtual reality navigational technology (VRNChair). J Exp Neurosci 8:7
doi: 10.4137/JEN.S13448
White P, Byagowi A, Moussavi Z (2018) VRNChair shortened, https://www.youtube.com/watch?v=ww5o67pJIXo
Moussavi Z, et al (2021) Repeated transcranial magnetic stimulation for improving cognition in patients with Alzheimer disease: protocol for a randomized, double-blind, placebo-controlled trial. JMIR Res Protoc 10(1)
Moussavi Z et al (2021) A novel program to improve cognitive function in individuals with dementia using transcranial alternating current stimulation (tACS) and tutored cognitive exercises. Front Aging 2(3)
Moussavi Z (2012) The effect of rTMS treatment on Alzheimer’s and sleep quality. NIH: US National Library of Medicine: https://clinicaltrials.gov/
Masoumzadeh S, Moussavi Z (2020) Does practicing with a virtual reality driving simulator improve spatial cognition in older adults? A pilot study. Neurosci Insights 15
Tu S et al (2015) Lost in spatial translation - a novel tool to objectively assess spatial disorientation in Alzheimer’s disease and frontotemporal dementia. Cortex 67:83–94
doi: 10.1016/j.cortex.2015.03.016
Puthusseryppady V et al (2020) Spatial disorientation in Alzheimer’s disease: the missing path from virtual reality to real world. Front Aging Neurosci 12:550514–550514
doi: 10.3389/fnagi.2020.550514
Rajan KB et al (2015) Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia. Neurology 85(10):898–904
doi: 10.1212/WNL.0000000000001774
Benussi A et al (2017) Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia. Neurology 89. https://doi.org/10.1212/WNL.0000000000004232
Benussi A et al (2021) Classification accuracy of TMS for the diagnosis of mild cognitive impairment. Brain Stimul 14(2):241–249
doi: 10.1016/j.brs.2021.01.004
Lithgow BJ et al (2021) Physiological separation of Alzheimer’s disease and Alzheimer’s disease with significant levels of cerebrovascular symptomology and healthy controls. Med Biol Eng Comput 59(7–8):1597–1610
doi: 10.1007/s11517-021-02409-8
Ranjbar Pouya O, Moussavi Z (2018) Practice effect in spatial updating: a longitudinal study using virtual reality navigation, in Int. Conf on Spatial Cognition (ICSC). Cognitive Processing, Rome, Italy, pp S49–S50
Liu I et al (2011) Age and gender differences in various topographical orientation strategies. Brain Res 1410:112–119
doi: 10.1016/j.brainres.2011.07.005
Ranjbar-Pouya O et al (2017) Introducing a new age-and-cognition-sensitive measurement or assessing spatial orientation using a landmark-less virtual reality navigational task. Q J Exp Psychol 70(7):1406–1419
doi: 10.1080/17470218.2016.1187181
White PJF, Moussavi Z (2016) Neurocognitive treatment for a patient with Alzheimer’s disease using a virtual reality navigational environment. J Exp Neurosci 10:129–135
doi: 10.4137/JEN.S40827